Formal synthesis of merrilactone a using a domino cyanide 1,4-addition-aldol cyclization

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A formal synthesis of merrilactone A has been completed using a domino 1,4-addition-aldol process as the key step. Both iodo- and cyano-1,4-addition- aldol cyclizations were productive in forming the highly hindered C1-C9 bond linking vic-quaternary and tertiary stereocenters. The latter method was used to complete a formal total synthesis of the natural product. © 2012 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)3720-3723
Number of pages3
JournalOrganic Letters
Issue number14
StatePublished - 20 Jul 2012