Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial.

Research output: Contribution to journalArticle

  • Authors:
  • William W Busse
  • Eugene R Bleecker
  • Eric D Bateman
  • Jan Lötvall
  • Richard Forth
  • And 4 others
  • External authors:
  • Angela M Davis
  • Loretta Jacques
  • Brett Haumann
  • Ashley Woodcock

Abstract

BACKGROUND: Fluticasone furoate (FF) is a novel inhaled corticosteroid with 24 h activity. FF is being developed as a once-daily treatment in combination with the long-acting β(2) agonist vilanterol trifenatate for asthma and chronic obstructive pulmonary disease. OBJECTIVES: To determine the optimal dose(s) of FF for treating patients with asthma. METHODS: An 8-week multicentre, randomised, double-blind study. 627 patients with persistent moderate-to-severe asthma, symptomatic on medium-dose inhaled corticosteroid therapy, were randomised to placebo, FF 200, 400, 600 or 800 μg (once daily in the evening using a novel dry powder inhaler), or fluticasone propionate 500 μg twice daily (via Diskus™/Accuhaler™). The primary efficacy measure was mean change from baseline in pre-dose evening forced expiratory volume in one second (FEV(1)). Other endpoints included morning and evening peak expiratory flow, and rescue/symptom-free 24 h periods. RESULTS: Each dose was significantly superior to placebo for the primary endpoint (p

Bibliographical metadata

Original languageEnglish
Pages (from-to)35-41
Number of pages6
JournalThorax
Volume67
Issue number1
DOIs
Publication statusPublished - Jan 2012