Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Wei-Tao Dou
  • Li-Fang Liu
  • Jie Gao
  • Yi Zang
  • Guo-Rong Chen
  • Tony D. James
  • Jia Li
  • Xiao-Peng He

Abstract

Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.

Bibliographical metadata

Original languageEnglish
JournalChemical Communications
DOIs
Publication statusPublished - 2 Oct 2019