Exposure to Ultraviolet Radiation in the Modulation of Human DiseasesCitation formats

Standard

Exposure to Ultraviolet Radiation in the Modulation of Human Diseases. / Hart, Prue H; Norval, Mary; Byrne, Scott N; Rhodes, Lesley E.

In: Annual Review of Pathology: Mechanisms of Disease, 01.2019.

Research output: Contribution to journalReview article

Harvard

APA

Hart, P. H., Norval, M., Byrne, S. N., & Rhodes, L. E. (2019). Exposure to Ultraviolet Radiation in the Modulation of Human Diseases. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathmechdis-012418-012809

Vancouver

Hart PH, Norval M, Byrne SN, Rhodes LE. Exposure to Ultraviolet Radiation in the Modulation of Human Diseases. Annual Review of Pathology: Mechanisms of Disease. 2019 Jan. https://doi.org/10.1146/annurev-pathmechdis-012418-012809

Author

Hart, Prue H ; Norval, Mary ; Byrne, Scott N ; Rhodes, Lesley E. / Exposure to Ultraviolet Radiation in the Modulation of Human Diseases. In: Annual Review of Pathology: Mechanisms of Disease. 2019.

Bibtex

@article{f257c0505dc342889af937b638cbc516,
title = "Exposure to Ultraviolet Radiation in the Modulation of Human Diseases",
abstract = "This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation (UVR). UVR stimulates anti-inflammatory and immunosuppressive pathways in skin that modulate psoriasis, atopic dermatitis, and vitiligo; suppresses cutaneous lesions of graft-versus-host disease; and regulates some infection and vaccination outcomes. While polymorphic light eruption and the cutaneous photosensitivity of systemic lupus erythematosus are triggered by UVR, polymorphic light eruption also frequently benefits from UVR-induced immunomodulation. For systemic diseases such as multiple sclerosis, type 1 diabetes, asthma, schizophrenia, autism, and cardiovascular disease, any positive consequences of UVR exposure are more speculative, but could occur through the actions of UVR-induced regulatory cells and mediators, including 1,25-dihydroxy vitamin D3, interleukin-10, and nitric oxide. Reduced UVR exposure is a risk factor for the development of several inflammatory, allergic, and autoimmune conditions, including diseases initiated in early life. This suggests that UVR-induced molecules can regulate cell maturation in developing organs. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease Volume 14 is January 24, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.",
author = "Hart, {Prue H} and Mary Norval and Byrne, {Scott N} and Rhodes, {Lesley E}",
year = "2019",
month = "1",
doi = "10.1146/annurev-pathmechdis-012418-012809",
language = "English",
journal = "Annual Review of Pathology: Mechanisms of Disease",
issn = "1553-4006",
publisher = "Annual Reviews Inc.",

}

RIS

TY - JOUR

T1 - Exposure to Ultraviolet Radiation in the Modulation of Human Diseases

AU - Hart, Prue H

AU - Norval, Mary

AU - Byrne, Scott N

AU - Rhodes, Lesley E

PY - 2019/1

Y1 - 2019/1

N2 - This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation (UVR). UVR stimulates anti-inflammatory and immunosuppressive pathways in skin that modulate psoriasis, atopic dermatitis, and vitiligo; suppresses cutaneous lesions of graft-versus-host disease; and regulates some infection and vaccination outcomes. While polymorphic light eruption and the cutaneous photosensitivity of systemic lupus erythematosus are triggered by UVR, polymorphic light eruption also frequently benefits from UVR-induced immunomodulation. For systemic diseases such as multiple sclerosis, type 1 diabetes, asthma, schizophrenia, autism, and cardiovascular disease, any positive consequences of UVR exposure are more speculative, but could occur through the actions of UVR-induced regulatory cells and mediators, including 1,25-dihydroxy vitamin D3, interleukin-10, and nitric oxide. Reduced UVR exposure is a risk factor for the development of several inflammatory, allergic, and autoimmune conditions, including diseases initiated in early life. This suggests that UVR-induced molecules can regulate cell maturation in developing organs. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease Volume 14 is January 24, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

AB - This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation (UVR). UVR stimulates anti-inflammatory and immunosuppressive pathways in skin that modulate psoriasis, atopic dermatitis, and vitiligo; suppresses cutaneous lesions of graft-versus-host disease; and regulates some infection and vaccination outcomes. While polymorphic light eruption and the cutaneous photosensitivity of systemic lupus erythematosus are triggered by UVR, polymorphic light eruption also frequently benefits from UVR-induced immunomodulation. For systemic diseases such as multiple sclerosis, type 1 diabetes, asthma, schizophrenia, autism, and cardiovascular disease, any positive consequences of UVR exposure are more speculative, but could occur through the actions of UVR-induced regulatory cells and mediators, including 1,25-dihydroxy vitamin D3, interleukin-10, and nitric oxide. Reduced UVR exposure is a risk factor for the development of several inflammatory, allergic, and autoimmune conditions, including diseases initiated in early life. This suggests that UVR-induced molecules can regulate cell maturation in developing organs. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease Volume 14 is January 24, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

U2 - 10.1146/annurev-pathmechdis-012418-012809

DO - 10.1146/annurev-pathmechdis-012418-012809

M3 - Review article

JO - Annual Review of Pathology: Mechanisms of Disease

T2 - Annual Review of Pathology: Mechanisms of Disease

JF - Annual Review of Pathology: Mechanisms of Disease

SN - 1553-4006

ER -