Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells.

Research output: Contribution to journalArticle

  • External authors:
  • Katherine A Hollywood
  • Catherine L Winder
  • Warwick B Dunn
  • Yun Xu
  • David Broadhurst


Psoriasis is a common, immune-mediated inflammatory skin disease characterized by red, heavily scaled plaques. The disease affects over one million people in the UK and causes significant physical, psychological and societal impact. There is limited understanding regarding the exact pathogenesis of the disease although it is believed to be a consequence of genetic predisposition and environmental triggers. Treatments vary from topical therapies, such as dithranol, for disease of limited extent (

Bibliographical metadata

Original languageEnglish
JournalMolecular BioSystems
Issue number8
StatePublished - Aug 2015