Exhaled Volatile Organic Compounds of Infection: A Systematic ReviewCitation formats

Standard

Exhaled Volatile Organic Compounds of Infection: A Systematic Review. / Ahmed, Waqar M; Lawal, Oluwasola; Nijsen, Tamara M; Goodacre, Royston; Fowler, Stephen J.

In: ACS Infectious Diseases, Vol. 3, No. 10, 13.10.2017, p. 695-710.

Research output: Contribution to journalArticlepeer-review

Harvard

Ahmed, WM, Lawal, O, Nijsen, TM, Goodacre, R & Fowler, SJ 2017, 'Exhaled Volatile Organic Compounds of Infection: A Systematic Review', ACS Infectious Diseases, vol. 3, no. 10, pp. 695-710. https://doi.org/10.1021/acsinfecdis.7b00088

APA

Vancouver

Ahmed WM, Lawal O, Nijsen TM, Goodacre R, Fowler SJ. Exhaled Volatile Organic Compounds of Infection: A Systematic Review. ACS Infectious Diseases. 2017 Oct 13;3(10):695-710. https://doi.org/10.1021/acsinfecdis.7b00088

Author

Ahmed, Waqar M ; Lawal, Oluwasola ; Nijsen, Tamara M ; Goodacre, Royston ; Fowler, Stephen J. / Exhaled Volatile Organic Compounds of Infection: A Systematic Review. In: ACS Infectious Diseases. 2017 ; Vol. 3, No. 10. pp. 695-710.

Bibtex

@article{4128e0bd44344aef9e57c7f2c388c156,
title = "Exhaled Volatile Organic Compounds of Infection: A Systematic Review",
abstract = "With heightened global concern of microbial drug resistance, advanced methods for early and accurate diagnosis of infection are urgently needed. Analysis of exhaled breath volatile organic compounds (VOCs) toward detecting microbial infection potentially allows a highly informative and noninvasive alternative to current genomics and culture-based methods. We performed a systematic review of research literature reporting human and animal exhaled breath VOCs related to microbial infections. In this Review, we find that a wide range of breath sampling and analysis methods are used by researchers, which significantly affects interstudy method comparability. Studies either perform targeted analysis of known VOCs relating to an infection, or non-targeted analysis to obtain a global profile of volatile metabolites. In general, the field of breath analysis is still relatively immature, and there is much to be understood about the metabolic production of breath VOCs, particularly in a host where both commensal microflora as well as pathogenic microorganisms may be manifested in the airways. We anticipate that measures to standardize high throughput sampling and analysis, together with an increase in large scale collaborative international trials, will bring routine breath VOC analysis to improve diagnosis of infection closer to reality.",
keywords = "Journal Article",
author = "Ahmed, {Waqar M} and Oluwasola Lawal and Nijsen, {Tamara M} and Royston Goodacre and Fowler, {Stephen J}",
year = "2017",
month = oct,
day = "13",
doi = "10.1021/acsinfecdis.7b00088",
language = "English",
volume = "3",
pages = "695--710",
journal = "ACS Infectious Diseases",
issn = "2373-8227",
publisher = "American Chemical Society",
number = "10",

}

RIS

TY - JOUR

T1 - Exhaled Volatile Organic Compounds of Infection: A Systematic Review

AU - Ahmed, Waqar M

AU - Lawal, Oluwasola

AU - Nijsen, Tamara M

AU - Goodacre, Royston

AU - Fowler, Stephen J

PY - 2017/10/13

Y1 - 2017/10/13

N2 - With heightened global concern of microbial drug resistance, advanced methods for early and accurate diagnosis of infection are urgently needed. Analysis of exhaled breath volatile organic compounds (VOCs) toward detecting microbial infection potentially allows a highly informative and noninvasive alternative to current genomics and culture-based methods. We performed a systematic review of research literature reporting human and animal exhaled breath VOCs related to microbial infections. In this Review, we find that a wide range of breath sampling and analysis methods are used by researchers, which significantly affects interstudy method comparability. Studies either perform targeted analysis of known VOCs relating to an infection, or non-targeted analysis to obtain a global profile of volatile metabolites. In general, the field of breath analysis is still relatively immature, and there is much to be understood about the metabolic production of breath VOCs, particularly in a host where both commensal microflora as well as pathogenic microorganisms may be manifested in the airways. We anticipate that measures to standardize high throughput sampling and analysis, together with an increase in large scale collaborative international trials, will bring routine breath VOC analysis to improve diagnosis of infection closer to reality.

AB - With heightened global concern of microbial drug resistance, advanced methods for early and accurate diagnosis of infection are urgently needed. Analysis of exhaled breath volatile organic compounds (VOCs) toward detecting microbial infection potentially allows a highly informative and noninvasive alternative to current genomics and culture-based methods. We performed a systematic review of research literature reporting human and animal exhaled breath VOCs related to microbial infections. In this Review, we find that a wide range of breath sampling and analysis methods are used by researchers, which significantly affects interstudy method comparability. Studies either perform targeted analysis of known VOCs relating to an infection, or non-targeted analysis to obtain a global profile of volatile metabolites. In general, the field of breath analysis is still relatively immature, and there is much to be understood about the metabolic production of breath VOCs, particularly in a host where both commensal microflora as well as pathogenic microorganisms may be manifested in the airways. We anticipate that measures to standardize high throughput sampling and analysis, together with an increase in large scale collaborative international trials, will bring routine breath VOC analysis to improve diagnosis of infection closer to reality.

KW - Journal Article

U2 - 10.1021/acsinfecdis.7b00088

DO - 10.1021/acsinfecdis.7b00088

M3 - Article

C2 - 28870074

VL - 3

SP - 695

EP - 710

JO - ACS Infectious Diseases

JF - ACS Infectious Diseases

SN - 2373-8227

IS - 10

ER -