Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Research output: Contribution to journalArticle

  • External authors:
  • Li Di
  • Per Artursson
  • Alex Avdeef
  • Gerhard F. Ecker
  • Bernard Faller
  • Holger Fischer
  • Manfred Kansy
  • Edward H. Kerns
  • Stefanie D. Krämer
  • Hans Lennernäs
  • Kiyohiko Sugano

Abstract

Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in drug bioavailability and disposition is discussed to refute the recently proposed theory that drug transport is CM-only and that new transporters will be discovered that possess transport characteristics ascribed to passive diffusion. Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization. © 2012 Elsevier Ltd.

Bibliographical metadata

Original languageEnglish
Pages (from-to)905-912
Number of pages7
JournalDrug discovery today
Volume17
Issue number15-16
DOIs
Publication statusPublished - Aug 2012