even-skipped determines the dorsal growth of motor axons in Drosophila

Research output: Contribution to journalArticle

  • Authors:
  • Matthias Landgraf
  • Sudipto Roy
  • Andreas Prokop
  • K. VijayRaghavan
  • Michael Bate

Abstract

Axon pathfinding and target choice are governed by cell type-specific responses to external cues. Here, we show that in the Drosophila embryo, motorneurons with targets in the dorsal muscle field express the homeobox gene even-skipped and that this expression is necessary and sufficient to direct motor axons into the dorsal muscle field. Previously, it was shown that motorneurons projecting to ventral targets express the LIM homeobox gene islet, which is sufficient to direct axons to the ventral muscle field. Thus, even-skipped complements the function of islet, and together these two genes constitute a bimodal switch regulating axonal growth and directing motor axons to ventral or to dorsal regions of the muscle field.

Bibliographical metadata

Original languageEnglish
Pages (from-to)43-52
Number of pages9
JournalNeuron
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1999