Evaluation of tumor shape variability in head-and-neck cancer patients over the course of radiation therapy using implanted gold markers.

Research output: Contribution to journalArticle

  • External authors:
  • Olga Hamming-Vrieze
  • Simon Robert van Kranen
  • Suzanne van Beek
  • Wilma Heemsbergen
  • Marcel van Herk
  • Michiel Wilhelmus Maria van den Brekel
  • Jan-Jakob Sonke
  • Coenraad Robert Nico Rasch


PURPOSE: This study quantifies tumor shape variability in head-and-neck cancer patients during radiation therapy using implanted markers. METHODS AND MATERIALS: Twenty-seven patients with oropharyngeal tumors treated with (chemo)radiation were included. Helical gold markers (0.35 × 2 mm, 3-10/patient, average 6) were implanted around the tumor. Markers were identified on planning computed tomography (CT) and daily cone beam CT (CBCT). After bony anatomy registration, the daily vector length on CBCT in reference to the planning CT and daily marker movement perpendicular to the gross tumor volume (GTV) surface at planning CT (d(normal)) of each marker were analyzed. Time trends were assessed with linear regression of the (markers). In 2 patients, 2 markers were implanted in normal tissue to evaluate migration by measuring intermarker distances. RESULTS: Marker implantation was feasible without complications. Three-dimensional vectors (4827 measurements, mean 0.23 cm, interquartile ratio 0.24 cm) were highest in base of tongue sublocalization (P

Bibliographical metadata

Original languageEnglish
JournalInternational journal of radiation oncology, biology, physics
Issue number2
Publication statusPublished - 1 Oct 2012