Evaluating the Evidence for Lymphatic Filariasis Elimination

Research output: Contribution to journalArticle

  • Authors:
  • Emma L. Davis
  • Lisa J. Reimer
  • Lorenzo Pellis
  • T. Deirdre Hollingsworth

Abstract

In the global drive for elimination of lymphatic filariasis (LF), 15 countries have achieved validation of elimination as a public health problem (EPHP). Recent empirical evidence has demonstrated that EPHP does not always lead to elimination of transmission (EOT). Here we show how the probability of elimination explicitly depends on key biological parameters, many of which have been poorly characterized, leading to a poor evidence base for the elimination threshold. As more countries progress towards EPHP it is essential that this process is well-informed, as prematurely halting treatment and surveillance programs could pose a serious threat to global progress. We highlight that refinement of the weak empirical evidence base is vital to understand drivers of elimination and inform long-term policy.

Bibliographical metadata

Original languageEnglish
Pages (from-to)860-869
Number of pages10
JournalTrends in parasitology
Volume35
Issue number11
Early online date7 Sep 2019
DOIs
Publication statusPublished - 1 Nov 2019