Ethertrum (Ethereum+Spectrum)is a live game-audio composition which examines how the relationship between humans and technology influenced the evolution of mankind. It musically embraces how we, as a species, enhanced our physical and mental abilities to became engineers of our own evolution, existence and inevitable extinction. A DNA Helix becomes the main character of an immersive game-audio journey across ancient and next-generation technologies. Using spectral sound and a rhombus-like environment (◊) - as the metaphor for the creation of life - each scene navigates a milestone in human metamorphosis. From a meteorite strike 4 billion years ago, followed by the sonification of cellular mitosis and pre-amphibian life, to early humans with hand-axe stones, leading to pyramids – not Egyptians but the techno-pyramid stage used by the French electronic music duo Daft Punk – to end with the merger between human and technology, while becoming data of a rhombus-shaped cryptocurrency called Ethereum. This project pushes the boundaries of existing research in composition using interactive media technology by successfully incorporating the concept of technological evolution into the compositional methods employed. For instance, artificial intelligence in game-engine software 4 is used to incorporate adaptive audio to the narrative (e.g. the drones sonically attacking the character in the pyramid scene have encoded behavioural instructions); or in the final ‘encrypted city’ section, the engine retrieves real-time ethereum statistics of cryptocurrency transactions on the web, to sonify a number of audio signal processes, a technology adopted by humans primarily because its high sense of ‘trust’ in the transaction process.