Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patientsCitation formats

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Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients. / Aarons, Leon; Ahmed, Ikhlas Ali; Deleu, Dirk.

In: Archives of Medical Research, Vol. 36, No. 1, 01.2005, p. 49-53.

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Aarons, Leon ; Ahmed, Ikhlas Ali ; Deleu, Dirk. / Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients. In: Archives of Medical Research. 2005 ; Vol. 36, No. 1. pp. 49-53.

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@article{adc9255030074ef1aa1f50e470974a44,
title = "Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients",
abstract = "Background. Serum concentrations of free-phenytoin (F-PHT) obtained in adult epileptic patients receiving PHT in monotherapy were analyzed to estimate the Michaelis-Menten pharmacokinetic parameters. Methods. Steady-state F-PHT serum concentrations, PHT dosing history, and associated information were collected prospectively. The maximum metabolic rate (Vm) and Michaelis-Menten constant (Km) of F-PHT and their interindividual variability data were estimated using nonlinear mixed effects modeling (NONMEM). Results. Twenty-nine patients with two or more available steady-state F-PHT serum concentrations (total of 63 dose/serum concentration pairs) met the inclusion criteria. Patients were taking PHT (100-500 mg/day) in monotherapy. The population estimates of F-PHT for Vm and Km were 9.1 mg/kg/day and 7.3 mg/L, respectively. The model was prospectively evaluated in a small group (seven) of additional patients. Conclusions. The recommended daily dose in this population to achieve a F-PHT concentration of 1.5 mg/L is 6.1 mg/kg. {\circledC} 2005 IMSS. Published by Elsevier Inc.",
keywords = "Epilepsy, Michaelis-Menten kinetics, NONMEM, Oman, Phenytoin, Population pharmacokinetics, Protein binding",
author = "Leon Aarons and Ahmed, {Ikhlas Ali} and Dirk Deleu",
year = "2005",
month = "1",
doi = "10.1016/j.arcmed.2004.11.006",
language = "English",
volume = "36",
pages = "49--53",
journal = "Archives of Medical Research",
number = "1",

}

RIS

TY - JOUR

T1 - Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients

AU - Aarons, Leon

AU - Ahmed, Ikhlas Ali

AU - Deleu, Dirk

PY - 2005/1

Y1 - 2005/1

N2 - Background. Serum concentrations of free-phenytoin (F-PHT) obtained in adult epileptic patients receiving PHT in monotherapy were analyzed to estimate the Michaelis-Menten pharmacokinetic parameters. Methods. Steady-state F-PHT serum concentrations, PHT dosing history, and associated information were collected prospectively. The maximum metabolic rate (Vm) and Michaelis-Menten constant (Km) of F-PHT and their interindividual variability data were estimated using nonlinear mixed effects modeling (NONMEM). Results. Twenty-nine patients with two or more available steady-state F-PHT serum concentrations (total of 63 dose/serum concentration pairs) met the inclusion criteria. Patients were taking PHT (100-500 mg/day) in monotherapy. The population estimates of F-PHT for Vm and Km were 9.1 mg/kg/day and 7.3 mg/L, respectively. The model was prospectively evaluated in a small group (seven) of additional patients. Conclusions. The recommended daily dose in this population to achieve a F-PHT concentration of 1.5 mg/L is 6.1 mg/kg. © 2005 IMSS. Published by Elsevier Inc.

AB - Background. Serum concentrations of free-phenytoin (F-PHT) obtained in adult epileptic patients receiving PHT in monotherapy were analyzed to estimate the Michaelis-Menten pharmacokinetic parameters. Methods. Steady-state F-PHT serum concentrations, PHT dosing history, and associated information were collected prospectively. The maximum metabolic rate (Vm) and Michaelis-Menten constant (Km) of F-PHT and their interindividual variability data were estimated using nonlinear mixed effects modeling (NONMEM). Results. Twenty-nine patients with two or more available steady-state F-PHT serum concentrations (total of 63 dose/serum concentration pairs) met the inclusion criteria. Patients were taking PHT (100-500 mg/day) in monotherapy. The population estimates of F-PHT for Vm and Km were 9.1 mg/kg/day and 7.3 mg/L, respectively. The model was prospectively evaluated in a small group (seven) of additional patients. Conclusions. The recommended daily dose in this population to achieve a F-PHT concentration of 1.5 mg/L is 6.1 mg/kg. © 2005 IMSS. Published by Elsevier Inc.

KW - Epilepsy

KW - Michaelis-Menten kinetics

KW - NONMEM

KW - Oman

KW - Phenytoin

KW - Population pharmacokinetics

KW - Protein binding

U2 - 10.1016/j.arcmed.2004.11.006

DO - 10.1016/j.arcmed.2004.11.006

M3 - Article

VL - 36

SP - 49

EP - 53

JO - Archives of Medical Research

JF - Archives of Medical Research

IS - 1

ER -