Establishing task- and modality-dependent dissociations between the semantic and default mode networks.Citation formats

Standard

Establishing task- and modality-dependent dissociations between the semantic and default mode networks. / Humphreys, G.F.; Hoffman, P.; Visser, M.; Binney, R.J.; Lambon Ralph, Matthew.

In: Proceedings of the National Academy of Sciences, Vol. 112, No. 25, 23.06.2015, p. 7857-7862.

Research output: Contribution to journalArticle

Harvard

Humphreys, GF, Hoffman, P, Visser, M, Binney, RJ & Lambon Ralph, M 2015, 'Establishing task- and modality-dependent dissociations between the semantic and default mode networks.', Proceedings of the National Academy of Sciences, vol. 112, no. 25, pp. 7857-7862. https://doi.org/10.1073/pnas.1422760112

APA

Humphreys, G. F., Hoffman, P., Visser, M., Binney, R. J., & Lambon Ralph, M. (2015). Establishing task- and modality-dependent dissociations between the semantic and default mode networks. Proceedings of the National Academy of Sciences, 112(25), 7857-7862. https://doi.org/10.1073/pnas.1422760112

Vancouver

Humphreys GF, Hoffman P, Visser M, Binney RJ, Lambon Ralph M. Establishing task- and modality-dependent dissociations between the semantic and default mode networks. Proceedings of the National Academy of Sciences. 2015 Jun 23;112(25):7857-7862. https://doi.org/10.1073/pnas.1422760112

Author

Humphreys, G.F. ; Hoffman, P. ; Visser, M. ; Binney, R.J. ; Lambon Ralph, Matthew. / Establishing task- and modality-dependent dissociations between the semantic and default mode networks. In: Proceedings of the National Academy of Sciences. 2015 ; Vol. 112, No. 25. pp. 7857-7862.

Bibtex

@article{fb4f78866ff246a4a87ab4a81132c4b2,
title = "Establishing task- and modality-dependent dissociations between the semantic and default mode networks.",
abstract = "The default mode network (DMN) and semantic network (SN) are two of the most extensively studied systems, and both are increasingly used as clinical biomarkers in neurological studies. There are strong theoretical reasons to assume a relationship between the networks, as well as anatomical evidence that they might rely on overlapping cortical regions, such as the anterior temporal lobe (ATL) or angular gyrus (AG). Despite these strong motivations, the relationship between the two systems has received minimal attention. We directly compared the SN and DMN using a large (n = 69) distortion-corrected functional MRI (fMRI) dataset, spanning a range of semantic and nonsemantic tasks that varied input modality. The results showed that both networks fractionate depending on the semantic nature of the task, stimulus type, modality, and task difficulty. Furthermore, despite recent claims that both AG and ATL are semantic hubs, the two areas responded very differently, with results supporting the role of ATL, but not AG, in semantic representation. Specifically, the left ATL was positively activated for all semantic tasks, but deactivated during nonsemantic task performance. In contrast, the left AG was deactivated for all tasks, with the level of deactivation related to task difficulty. Thus, ATL and AG do not share a common interest in semantic tasks, but, rather, a common {"}disinterest{"} in nonsemantic tasks. The implications for the variability in the DMN, its cognitive coherence, and interpretation of resting-state fMRI data are discussed.",
keywords = "angular gyrus, anterior temporal lobe, default mode network, distortion-corrected fMRI, semantic network",
author = "G.F. Humphreys and P. Hoffman and M. Visser and R.J. Binney and {Lambon Ralph}, Matthew",
note = "MR/J004146/1, Medical Research Council, United Kingdom",
year = "2015",
month = "6",
day = "23",
doi = "10.1073/pnas.1422760112",
language = "English",
volume = "112",
pages = "7857--7862",
journal = "Proceedings of the National Academy of Sciences",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "25",

}

RIS

TY - JOUR

T1 - Establishing task- and modality-dependent dissociations between the semantic and default mode networks.

AU - Humphreys, G.F.

AU - Hoffman, P.

AU - Visser, M.

AU - Binney, R.J.

AU - Lambon Ralph, Matthew

N1 - MR/J004146/1, Medical Research Council, United Kingdom

PY - 2015/6/23

Y1 - 2015/6/23

N2 - The default mode network (DMN) and semantic network (SN) are two of the most extensively studied systems, and both are increasingly used as clinical biomarkers in neurological studies. There are strong theoretical reasons to assume a relationship between the networks, as well as anatomical evidence that they might rely on overlapping cortical regions, such as the anterior temporal lobe (ATL) or angular gyrus (AG). Despite these strong motivations, the relationship between the two systems has received minimal attention. We directly compared the SN and DMN using a large (n = 69) distortion-corrected functional MRI (fMRI) dataset, spanning a range of semantic and nonsemantic tasks that varied input modality. The results showed that both networks fractionate depending on the semantic nature of the task, stimulus type, modality, and task difficulty. Furthermore, despite recent claims that both AG and ATL are semantic hubs, the two areas responded very differently, with results supporting the role of ATL, but not AG, in semantic representation. Specifically, the left ATL was positively activated for all semantic tasks, but deactivated during nonsemantic task performance. In contrast, the left AG was deactivated for all tasks, with the level of deactivation related to task difficulty. Thus, ATL and AG do not share a common interest in semantic tasks, but, rather, a common "disinterest" in nonsemantic tasks. The implications for the variability in the DMN, its cognitive coherence, and interpretation of resting-state fMRI data are discussed.

AB - The default mode network (DMN) and semantic network (SN) are two of the most extensively studied systems, and both are increasingly used as clinical biomarkers in neurological studies. There are strong theoretical reasons to assume a relationship between the networks, as well as anatomical evidence that they might rely on overlapping cortical regions, such as the anterior temporal lobe (ATL) or angular gyrus (AG). Despite these strong motivations, the relationship between the two systems has received minimal attention. We directly compared the SN and DMN using a large (n = 69) distortion-corrected functional MRI (fMRI) dataset, spanning a range of semantic and nonsemantic tasks that varied input modality. The results showed that both networks fractionate depending on the semantic nature of the task, stimulus type, modality, and task difficulty. Furthermore, despite recent claims that both AG and ATL are semantic hubs, the two areas responded very differently, with results supporting the role of ATL, but not AG, in semantic representation. Specifically, the left ATL was positively activated for all semantic tasks, but deactivated during nonsemantic task performance. In contrast, the left AG was deactivated for all tasks, with the level of deactivation related to task difficulty. Thus, ATL and AG do not share a common interest in semantic tasks, but, rather, a common "disinterest" in nonsemantic tasks. The implications for the variability in the DMN, its cognitive coherence, and interpretation of resting-state fMRI data are discussed.

KW - angular gyrus

KW - anterior temporal lobe

KW - default mode network

KW - distortion-corrected fMRI

KW - semantic network

U2 - 10.1073/pnas.1422760112

DO - 10.1073/pnas.1422760112

M3 - Article

VL - 112

SP - 7857

EP - 7862

JO - Proceedings of the National Academy of Sciences

T2 - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 0027-8424

IS - 25

ER -