Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Research output: Contribution to journalArticle

  • Authors:
  • U-BIOPRED Study Group

Abstract

astro-oesophageal reflux disease (GORD) and obesity are associated with frequent exacerbations and poor quality of life in asthmatics. Multiple mechanisms have been proposed for the effect of obesity, including modification of inflammation affecting epithelial cell proliferation and wound repair, while the role of GORD is poorly understood and proton pump inhibitor (PPI) are of variable efficacy. GORD might exert a deleterious effect by inducing vagal reflex, neuroinflammation and directly (via microaspiration) triggering airway inflammation. Studies of reflux in animal models and human bronchial epithelial cell culture show varying impact on inflammation and airway remodelling.

Bibliographical metadata

Original languageEnglish
JournalThe European respiratory journal
Early online date25 Apr 2019
DOIs
Publication statusPublished - 27 Jun 2019