Epidemiology of posttransplantation lymphoproliferative disorder in adult renal transplant recipients.

Research output: Contribution to journalArticle

  • External authors:
  • Muir Morton
  • Beatrice Coupes
  • Paul E Klapper
  • Kate Ryan
  • Michael L Picton

Abstract

Background. There is little information in the literature describing the relationship between posttransplantation lym- phoproliferative disorder (PTLD) incidence and presentation with both recipient Epstein-Barr virus (EBV) serostatus and EBV status of PTLD histology, particularly in the late posttransplantation period. Methods. This study reports the largestUK single-center, single-organ analysis of PTLD to date in a retrospective cohort study of 80 cases occurring in 4189 adult renal transplant recipients. Results. The incidence rate was 2.6 cases per 1000 patient-years (95%confidence interval [95% CI], 2.1Y3.2) for PTLD, 1.8 (95% CI, 1.4Y2.4) for non-Hodgkin’s lymphoma, and 0.2 (95% CI, 0.07Y4.2) for Hodgkin’s lymphoma. Non- Hodgkin’s lymphoma occurred at a rate 7.6 times that of the adult general population in England, whereas the rate for Hodgkin’s lymphoma was 5.9 times. The incidence of PTLD was highest during the 10th to 14th posttransplantation years. Early-onset disease was associated with EBV-seronegative recipient status, EBV-positive histology, and the in- volvement of extranodal sites. PTLD occurring in EBV-seronegative recipients was associated with EBV nuclear antigen antibody deficiency, polymorphic disease, and the involvement of extranodal sites. EBV-negative histology occurred in 32%of cases at amedian time to presentation of 109months. PTLD involving the allograft, central nervous system, and skin was uncommon and occurred late. Conclusion. The incidence of PTLD is highest in the late posttransplantation period. Close clinical surveillance and education for transplant recipients is required for the duration of time while immunosuppressed. Failure to detect EBV DNA in blood should not reassure, particularly in patients with symptoms such as abdominal pain, oropharyngeal complaints, neck lumps, and B-symptoms.

Bibliographical metadata

Original languageEnglish
Pages (from-to)470-478
Number of pages8
JournalTransplantation
Volume95
Issue number3
DOIs
Publication statusPublished - 15 Feb 2013