Enzyme-catalyzed enantioselective hydrolysis of dihydrouracils as a route to enantiomerically pure Β-amino acids

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The hydantoinase from Vigna angularis has been shown to catalysis the hydrolysis of a range of racemic 6-substituted dihydrouracils to yield the corresponding N-carbamoyl-(S)-Β-amino acids and unreacted (R)-dihydrouracils. High enantioselectivity (E >100) was achieved in cases that the C-6 substituent was an aryl group. Subsequent treatment of the N-carbamoyl derivatives with nitrous acid yielded the free Β-amino acid. © 2011 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1014-1016
Number of pages2
JournalACS Catalysis
Issue number9
Publication statusPublished - 2 Sep 2011