Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • S. B. Donaldson
  • D. L. Buckley
  • S. E. Davidson
  • B. M. Carrington
  • A. P. Jones


Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E F) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F (P0.011).Interpretation:E F is a simple imaging biomarker that should be studied further in a multi-centre setting. © 2010 Cancer Research UK All rights reserved.

Bibliographical metadata

Original languageEnglish
Pages (from-to)23-26
Number of pages3
JournalBritish Journal of Cancer
Issue number1
Publication statusPublished - Jan 2010