Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix
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Abstract
Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E F) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F (P0.011).Interpretation:E F is a simple imaging biomarker that should be studied further in a multi-centre setting. © 2010 Cancer Research UK All rights reserved.
Bibliographical metadata
Original language | English |
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Pages (from-to) | 23-26 |
Number of pages | 3 |
Journal | British Journal of Cancer |
Volume | 102 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2010 |