Enhancement and suppression in a lexical interference fMRI-paradigmCitation formats

  • Authors:
  • Stefanie Abel
  • Katharina Dressel
  • Cornelius Weiller
  • Walter Huber

Standard

Enhancement and suppression in a lexical interference fMRI-paradigm. / Abel, Stefanie; Dressel, Katharina; Weiller, Cornelius; Huber, Walter.

In: Brain and Behavior, Vol. 2, No. 2, 03.2012, p. 109-127.

Research output: Contribution to journalArticle

Harvard

Abel, S, Dressel, K, Weiller, C & Huber, W 2012, 'Enhancement and suppression in a lexical interference fMRI-paradigm', Brain and Behavior, vol. 2, no. 2, pp. 109-127. https://doi.org/10.1002/brb3.31

APA

Abel, S., Dressel, K., Weiller, C., & Huber, W. (2012). Enhancement and suppression in a lexical interference fMRI-paradigm. Brain and Behavior, 2(2), 109-127. https://doi.org/10.1002/brb3.31

Vancouver

Abel S, Dressel K, Weiller C, Huber W. Enhancement and suppression in a lexical interference fMRI-paradigm. Brain and Behavior. 2012 Mar;2(2):109-127. https://doi.org/10.1002/brb3.31

Author

Abel, Stefanie ; Dressel, Katharina ; Weiller, Cornelius ; Huber, Walter. / Enhancement and suppression in a lexical interference fMRI-paradigm. In: Brain and Behavior. 2012 ; Vol. 2, No. 2. pp. 109-127.

Bibtex

@article{ae00a676df90464eb55284fe48a27947,
title = "Enhancement and suppression in a lexical interference fMRI-paradigm",
abstract = "Previous picture-word interference (PWI) fMRI-paradigms revealed ambiguous mechanisms underlying facilitation and inhibition in healthy subjects. Lexical distractors revealed increased (enhancement) or decreased (suppression) activation in language and monitoring/control areas. Performing a secondary examination and data analysis, we aimed to illuminate the relation between behavioral and neural interference effects comparing target-related distractors (REL) with unrelated distractors (UNREL). We hypothesized that interference involves both (A) suppression due to priming and (B) enhancement due to simultaneous distractor and target processing. Comparisons to UNREL should remain distractor unspecific even at a low threshold. (C) Distractor types with common characteristics should reveal overlapping brain areas. In a 3T MRI scanner, participants were asked to name pictures while auditory words were presented (stimulus onset asynchrony [SOA] = -200 msec). Associatively and phonologically related distractors speeded responses (facilitation), while categorically related distractors slowed them down (inhibition) compared to UNREL. As a result, (A) reduced brain activations indeed resembled previously reported patterns of neural priming. Each target-related distractor yielded suppressions at least in areas associated with vision and conflict/competition monitoring (anterior cingulate cortex [ACC]), revealing least priming for inhibitors. (B) Enhancements concerned language-related but distractor-unspecific regions. (C) Some wider brain regions were commonly suppressed for combinations of distractor types. Overlapping areas associated with conceptual priming were found for facilitatory distractors (inferior frontal gyri), and areas related to phonetic/articulatory processing (precentral gyri and left parietal operculum/insula) for distractors sharing feature overlap. Each distractor with semantic relatedness revealed nonoverlapping suppressions in lexical-phonological areas (superior temporal regions). To conclude, interference combines suppression of areas well known from neural priming and enhancement of language-related areas caused by dual activation from target and distractor. Differences between interference and priming need to be taken into account. The present interference paradigm has the potential to reveal the functioning of word-processing stages, cognitive control, and responsiveness to priming at the same time. {\circledC} 2012 The Authors.",
keywords = "Facilitation, FMRI, Inhibition, Naming, Picture-word interference task, Semantic priming, Visual object priming, Word processing",
author = "Stefanie Abel and Katharina Dressel and Cornelius Weiller and Walter Huber",
year = "2012",
month = "3",
doi = "10.1002/brb3.31",
language = "English",
volume = "2",
pages = "109--127",
journal = "Brain and Behavior",
issn = "2162-3279",
publisher = "John Wiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Enhancement and suppression in a lexical interference fMRI-paradigm

AU - Abel, Stefanie

AU - Dressel, Katharina

AU - Weiller, Cornelius

AU - Huber, Walter

PY - 2012/3

Y1 - 2012/3

N2 - Previous picture-word interference (PWI) fMRI-paradigms revealed ambiguous mechanisms underlying facilitation and inhibition in healthy subjects. Lexical distractors revealed increased (enhancement) or decreased (suppression) activation in language and monitoring/control areas. Performing a secondary examination and data analysis, we aimed to illuminate the relation between behavioral and neural interference effects comparing target-related distractors (REL) with unrelated distractors (UNREL). We hypothesized that interference involves both (A) suppression due to priming and (B) enhancement due to simultaneous distractor and target processing. Comparisons to UNREL should remain distractor unspecific even at a low threshold. (C) Distractor types with common characteristics should reveal overlapping brain areas. In a 3T MRI scanner, participants were asked to name pictures while auditory words were presented (stimulus onset asynchrony [SOA] = -200 msec). Associatively and phonologically related distractors speeded responses (facilitation), while categorically related distractors slowed them down (inhibition) compared to UNREL. As a result, (A) reduced brain activations indeed resembled previously reported patterns of neural priming. Each target-related distractor yielded suppressions at least in areas associated with vision and conflict/competition monitoring (anterior cingulate cortex [ACC]), revealing least priming for inhibitors. (B) Enhancements concerned language-related but distractor-unspecific regions. (C) Some wider brain regions were commonly suppressed for combinations of distractor types. Overlapping areas associated with conceptual priming were found for facilitatory distractors (inferior frontal gyri), and areas related to phonetic/articulatory processing (precentral gyri and left parietal operculum/insula) for distractors sharing feature overlap. Each distractor with semantic relatedness revealed nonoverlapping suppressions in lexical-phonological areas (superior temporal regions). To conclude, interference combines suppression of areas well known from neural priming and enhancement of language-related areas caused by dual activation from target and distractor. Differences between interference and priming need to be taken into account. The present interference paradigm has the potential to reveal the functioning of word-processing stages, cognitive control, and responsiveness to priming at the same time. © 2012 The Authors.

AB - Previous picture-word interference (PWI) fMRI-paradigms revealed ambiguous mechanisms underlying facilitation and inhibition in healthy subjects. Lexical distractors revealed increased (enhancement) or decreased (suppression) activation in language and monitoring/control areas. Performing a secondary examination and data analysis, we aimed to illuminate the relation between behavioral and neural interference effects comparing target-related distractors (REL) with unrelated distractors (UNREL). We hypothesized that interference involves both (A) suppression due to priming and (B) enhancement due to simultaneous distractor and target processing. Comparisons to UNREL should remain distractor unspecific even at a low threshold. (C) Distractor types with common characteristics should reveal overlapping brain areas. In a 3T MRI scanner, participants were asked to name pictures while auditory words were presented (stimulus onset asynchrony [SOA] = -200 msec). Associatively and phonologically related distractors speeded responses (facilitation), while categorically related distractors slowed them down (inhibition) compared to UNREL. As a result, (A) reduced brain activations indeed resembled previously reported patterns of neural priming. Each target-related distractor yielded suppressions at least in areas associated with vision and conflict/competition monitoring (anterior cingulate cortex [ACC]), revealing least priming for inhibitors. (B) Enhancements concerned language-related but distractor-unspecific regions. (C) Some wider brain regions were commonly suppressed for combinations of distractor types. Overlapping areas associated with conceptual priming were found for facilitatory distractors (inferior frontal gyri), and areas related to phonetic/articulatory processing (precentral gyri and left parietal operculum/insula) for distractors sharing feature overlap. Each distractor with semantic relatedness revealed nonoverlapping suppressions in lexical-phonological areas (superior temporal regions). To conclude, interference combines suppression of areas well known from neural priming and enhancement of language-related areas caused by dual activation from target and distractor. Differences between interference and priming need to be taken into account. The present interference paradigm has the potential to reveal the functioning of word-processing stages, cognitive control, and responsiveness to priming at the same time. © 2012 The Authors.

KW - Facilitation

KW - FMRI

KW - Inhibition

KW - Naming

KW - Picture-word interference task

KW - Semantic priming

KW - Visual object priming

KW - Word processing

U2 - 10.1002/brb3.31

DO - 10.1002/brb3.31

M3 - Article

VL - 2

SP - 109

EP - 127

JO - Brain and Behavior

T2 - Brain and Behavior

JF - Brain and Behavior

SN - 2162-3279

IS - 2

ER -