Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers

Research output: Contribution to journalArticle

  • External authors:
  • Cristian Samorì
  • Hanene Ali-Boucetta
  • Raquel Sainz
  • Chang Guo
  • Francesca Maria Toma
  • Chiara Fabbro
  • Tatiana Da Ros
  • Maurizio Prato
  • Alberto Bianco

Abstract

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker. © The Royal Society of Chemistry 2010.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1494-1496
Number of pages2
JournalChemical Communications
Volume46
Issue number9
DOIs
Publication statusPublished - 2010