Enantioselective generation of adjacent stereocentres via a copper-catalyzed three component coupling of imines, allenes and diboranes

Research output: Research - peer-reviewArticle


A highly enantio- and diastereoselective copper-catalyzed three-component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient temperature, couples readily available simple imines, allenes, and diboranes, and yields high-value homoallylic amines that exhibit versatile amino, alkenyl, and boryl units.

Bibliographical metadata

Original languageEnglish
Pages (from-to)11912-11916
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number39
Early online date19 Aug 2016
StatePublished - 12 Sep 2016