Enantioselective and Regioselective Copper-Catalyzed Borocyanation of 1-Aryl-1,3-Butadienes

Research output: Contribution to journalArticle


A multicomponent copper-catalyzed enantio- and regioselective borocyanation of 1-aryl-1,3-butadienes has been developed. The method provides access to functionalized allylic nitriles in up to 90% yield and 94% ee and thus overcomes some of the long-standing problems associated with the enantioselective insertion of cyano groups into unsaturated organic molecules. Both boron and cyano functionalities can be used as handles for selective manipulation.

Bibliographical metadata

Original languageEnglish
Pages (from-to)6744-6750
JournalACS Catalysis
Early online date28 Jun 2019
Publication statusPublished - 2019