Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Research output: Contribution to journalArticle

  • External authors:
  • Clare F. Megarity
  • Bhavin Siritanaratkul
  • Rachel S. Heath
  • Lei Wan
  • Giorgio Morello
  • Sarah R. FitzPatrick
  • Rosalind L. Booth
  • Adam J. Sills
  • Alexander W. Robertson
  • Jamie H. Warner
  • Fraser A. Armstrong

Abstract

In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP + are cycled rapidly between ferredoxin–NADP + reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.

Bibliographical metadata

Original languageEnglish
JournalAngewandte Chemie - International Edition
Early online date11 Jan 2019
DOIs
Publication statusPublished - 14 Feb 2019