Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Research output: Contribution to journalArticle

  • External authors:
  • Jeroen Van Den Bossche
  • Wafa T. Al-Jamal
  • Bowen Tian
  • Antonio Nunes
  • Chiara Fabbro
  • Alberto Bianco
  • Maurizio Prato

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications. © 2010 The Royal Society of Chemistry.

Bibliographical metadata

Original languageEnglish
Pages (from-to)7379-7381
Number of pages2
JournalChemical Communications
Volume46
Issue number39
DOIs
Publication statusPublished - 21 Oct 2010