Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer.Citation formats

  • External authors:
  • Vanessa Mexner
  • Jochem W H Wolthaus
  • Marcel van Herk
  • Eugène M F Damen
  • Jan-Jakob Sonke

Standard

Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer. / Van Herk, Marcel; Mexner, Vanessa; Wolthaus, Jochem W H; van Herk, Marcel; Damen, Eugène M F; Sonke, Jan-Jakob.

In: International journal of radiation oncology, biology, physics, Vol. 74, No. 4, 15.07.2009.

Research output: Contribution to journalArticle

Harvard

Van Herk, M, Mexner, V, Wolthaus, JWH, van Herk, M, Damen, EMF & Sonke, J-J 2009, 'Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer.', International journal of radiation oncology, biology, physics, vol. 74, no. 4. https://doi.org/10.1016/j.ijrobp.2009.02.073

APA

Van Herk, M., Mexner, V., Wolthaus, J. W. H., van Herk, M., Damen, E. M. F., & Sonke, J-J. (2009). Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer. International journal of radiation oncology, biology, physics, 74(4). https://doi.org/10.1016/j.ijrobp.2009.02.073

Vancouver

Van Herk M, Mexner V, Wolthaus JWH, van Herk M, Damen EMF, Sonke J-J. Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer. International journal of radiation oncology, biology, physics. 2009 Jul 15;74(4). https://doi.org/10.1016/j.ijrobp.2009.02.073

Author

Van Herk, Marcel ; Mexner, Vanessa ; Wolthaus, Jochem W H ; van Herk, Marcel ; Damen, Eugène M F ; Sonke, Jan-Jakob. / Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer. In: International journal of radiation oncology, biology, physics. 2009 ; Vol. 74, No. 4.

Bibtex

@article{0f91eeff8e514146b25051badd239937,
title = "Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer.",
abstract = "PURPOSE: To determine the effect of respiration-induced density variations on the estimated dose delivered to moving structures and, consequently, to evaluate the necessity of using full four-dimensional (4D) treatment plan optimization. METHODS AND MATERIALS: In 10 patients with large tumor motion (median, 1.9 cm; range, 1.1-3.6 cm), the clinical treatment plan, designed using the mid-ventilation ([MidV]; i.e., the 4D-CT frame closest to the time-averaged mean position) CT scan, was recalculated on all 4D-CT frames. The cumulative dose was determined by transforming the doses in all breathing phases to the MidV geometry using deformable registration and then averaging the results. To determine the effect of density variations, this cumulative dose was compared with the accumulated dose after similarly deforming the planned (3D) MidV-dose in each respiratory phase using the same transformation (i.e., {"}blurring the dose{"}). RESULTS: The accumulated tumor doses, including and excluding density variations, were almost identical. Relative differences in the minimum gross tumor volume (GTV) dose were less than 2{\%} for all patients. The relative differences were even smaller in the mean lung dose and the V20 (",
author = "{Van Herk}, Marcel and Vanessa Mexner and Wolthaus, {Jochem W H} and {van Herk}, Marcel and Damen, {Eug{\`e}ne M F} and Jan-Jakob Sonke",
year = "2009",
month = "7",
day = "15",
doi = "10.1016/j.ijrobp.2009.02.073",
language = "English",
volume = "74",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of respiration-induced density variations on dose distributions in radiotherapy of lung cancer.

AU - Van Herk, Marcel

AU - Mexner, Vanessa

AU - Wolthaus, Jochem W H

AU - van Herk, Marcel

AU - Damen, Eugène M F

AU - Sonke, Jan-Jakob

PY - 2009/7/15

Y1 - 2009/7/15

N2 - PURPOSE: To determine the effect of respiration-induced density variations on the estimated dose delivered to moving structures and, consequently, to evaluate the necessity of using full four-dimensional (4D) treatment plan optimization. METHODS AND MATERIALS: In 10 patients with large tumor motion (median, 1.9 cm; range, 1.1-3.6 cm), the clinical treatment plan, designed using the mid-ventilation ([MidV]; i.e., the 4D-CT frame closest to the time-averaged mean position) CT scan, was recalculated on all 4D-CT frames. The cumulative dose was determined by transforming the doses in all breathing phases to the MidV geometry using deformable registration and then averaging the results. To determine the effect of density variations, this cumulative dose was compared with the accumulated dose after similarly deforming the planned (3D) MidV-dose in each respiratory phase using the same transformation (i.e., "blurring the dose"). RESULTS: The accumulated tumor doses, including and excluding density variations, were almost identical. Relative differences in the minimum gross tumor volume (GTV) dose were less than 2% for all patients. The relative differences were even smaller in the mean lung dose and the V20 (

AB - PURPOSE: To determine the effect of respiration-induced density variations on the estimated dose delivered to moving structures and, consequently, to evaluate the necessity of using full four-dimensional (4D) treatment plan optimization. METHODS AND MATERIALS: In 10 patients with large tumor motion (median, 1.9 cm; range, 1.1-3.6 cm), the clinical treatment plan, designed using the mid-ventilation ([MidV]; i.e., the 4D-CT frame closest to the time-averaged mean position) CT scan, was recalculated on all 4D-CT frames. The cumulative dose was determined by transforming the doses in all breathing phases to the MidV geometry using deformable registration and then averaging the results. To determine the effect of density variations, this cumulative dose was compared with the accumulated dose after similarly deforming the planned (3D) MidV-dose in each respiratory phase using the same transformation (i.e., "blurring the dose"). RESULTS: The accumulated tumor doses, including and excluding density variations, were almost identical. Relative differences in the minimum gross tumor volume (GTV) dose were less than 2% for all patients. The relative differences were even smaller in the mean lung dose and the V20 (

U2 - 10.1016/j.ijrobp.2009.02.073

DO - 10.1016/j.ijrobp.2009.02.073

M3 - Article

C2 - 19545793

VL - 74

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 4

ER -