Effects of Global Atrophy, White Matter Lesions, and Cerebral Blood Flow on Age-Related Changes in Speed, Memory, Intelligence, Vocabulary, and Frontal FunctionCitation formats

  • External authors:
  • Patrick Rabbitt
  • Oemetse Mogapi
  • Marietta Scott
  • Christine Lowe
  • Mike Horan
  • Neil Pendleton
  • Dan Lunn

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Effects of Global Atrophy, White Matter Lesions, and Cerebral Blood Flow on Age-Related Changes in Speed, Memory, Intelligence, Vocabulary, and Frontal Function. / Rogers, Christine; Rabbitt, Patrick; Mogapi, Oemetse; Scott, Marietta; Thacker, Neil; Lowe, Christine; Horan, Mike; Pendleton, Neil; Jackson, Alan; Lunn, Dan.

In: Neuropsychology, Vol. 21, No. 6, 11.2007, p. 684-695.

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Rogers, Christine ; Rabbitt, Patrick ; Mogapi, Oemetse ; Scott, Marietta ; Thacker, Neil ; Lowe, Christine ; Horan, Mike ; Pendleton, Neil ; Jackson, Alan ; Lunn, Dan. / Effects of Global Atrophy, White Matter Lesions, and Cerebral Blood Flow on Age-Related Changes in Speed, Memory, Intelligence, Vocabulary, and Frontal Function. In: Neuropsychology. 2007 ; Vol. 21, No. 6. pp. 684-695.

Bibtex

@article{c82596cfe12a47bb8bde06bb5017bc3e,
title = "Effects of Global Atrophy, White Matter Lesions, and Cerebral Blood Flow on Age-Related Changes in Speed, Memory, Intelligence, Vocabulary, and Frontal Function",
abstract = "Brain images were obtained from 133 healthy people of ages 61-85 years who completed 20 tests of information processing speed, intelligence, frontal and executive function, memory, and vocabulary. Structural equation models examined relationships between cognitive test scores, ages and measurements of global age-associated atrophy, white matter lesions, and cerebral blood flow. These neurophysiological measures jointly account for all age-related variance in information processing speed. Speed entirely mediated relationships between neurophysiological measures and memory and partly mediated relationships between neurophysiological measures and intelligence and frontal function. Neurophysiological measures, but not calendar age, accounted for vocabulary scores. Cognitive slowing was responsible for some, but not all, age-related declines in mental function. Age-related declines in intelligence, frontal function, and speed were due to changes in different functional systems. {\textcopyright} 2007 American Psychological Association.",
keywords = "age, global brain changes, intelligence, memory, speed",
author = "Christine Rogers and Patrick Rabbitt and Oemetse Mogapi and Marietta Scott and Neil Thacker and Christine Lowe and Mike Horan and Neil Pendleton and Alan Jackson and Dan Lunn",
year = "2007",
month = nov,
doi = "10.1037/0894-4105.21.6.684",
language = "English",
volume = "21",
pages = "684--695",
journal = "Neuropsychology",
issn = "1931-1559",
publisher = "American Psychological Association",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of Global Atrophy, White Matter Lesions, and Cerebral Blood Flow on Age-Related Changes in Speed, Memory, Intelligence, Vocabulary, and Frontal Function

AU - Rogers, Christine

AU - Rabbitt, Patrick

AU - Mogapi, Oemetse

AU - Scott, Marietta

AU - Thacker, Neil

AU - Lowe, Christine

AU - Horan, Mike

AU - Pendleton, Neil

AU - Jackson, Alan

AU - Lunn, Dan

PY - 2007/11

Y1 - 2007/11

N2 - Brain images were obtained from 133 healthy people of ages 61-85 years who completed 20 tests of information processing speed, intelligence, frontal and executive function, memory, and vocabulary. Structural equation models examined relationships between cognitive test scores, ages and measurements of global age-associated atrophy, white matter lesions, and cerebral blood flow. These neurophysiological measures jointly account for all age-related variance in information processing speed. Speed entirely mediated relationships between neurophysiological measures and memory and partly mediated relationships between neurophysiological measures and intelligence and frontal function. Neurophysiological measures, but not calendar age, accounted for vocabulary scores. Cognitive slowing was responsible for some, but not all, age-related declines in mental function. Age-related declines in intelligence, frontal function, and speed were due to changes in different functional systems. © 2007 American Psychological Association.

AB - Brain images were obtained from 133 healthy people of ages 61-85 years who completed 20 tests of information processing speed, intelligence, frontal and executive function, memory, and vocabulary. Structural equation models examined relationships between cognitive test scores, ages and measurements of global age-associated atrophy, white matter lesions, and cerebral blood flow. These neurophysiological measures jointly account for all age-related variance in information processing speed. Speed entirely mediated relationships between neurophysiological measures and memory and partly mediated relationships between neurophysiological measures and intelligence and frontal function. Neurophysiological measures, but not calendar age, accounted for vocabulary scores. Cognitive slowing was responsible for some, but not all, age-related declines in mental function. Age-related declines in intelligence, frontal function, and speed were due to changes in different functional systems. © 2007 American Psychological Association.

KW - age

KW - global brain changes

KW - intelligence

KW - memory

KW - speed

U2 - 10.1037/0894-4105.21.6.684

DO - 10.1037/0894-4105.21.6.684

M3 - Article

C2 - 17983282

VL - 21

SP - 684

EP - 695

JO - Neuropsychology

JF - Neuropsychology

SN - 1931-1559

IS - 6

ER -