Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restrictionCitation formats

  • External authors:
  • Joanna L. Stanley
  • Irene J. Andersson
  • Cassandra J. Hirt
  • Linn Moore
  • Alejandro R. Chade
  • Sandra T. Davidge
  • Philip N. Baker

Standard

Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction. / Stanley, Joanna L.; Andersson, Irene J.; Hirt, Cassandra J.; Moore, Linn; Dilworth, Mark R.; Chade, Alejandro R.; Sibley, Colin P.; Davidge, Sandra T.; Baker, Philip N.

In: Biology of reproduction, Vol. 87, No. 1, 07.2012, p. 25.

Research output: Contribution to journalArticle

Harvard

Stanley, JL, Andersson, IJ, Hirt, CJ, Moore, L, Dilworth, MR, Chade, AR, Sibley, CP, Davidge, ST & Baker, PN 2012, 'Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction', Biology of reproduction, vol. 87, no. 1, pp. 25. https://doi.org/10.1095/biolreprod.111.096198

APA

Stanley, J. L., Andersson, I. J., Hirt, C. J., Moore, L., Dilworth, M. R., Chade, A. R., ... Baker, P. N. (2012). Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction. Biology of reproduction, 87(1), 25. https://doi.org/10.1095/biolreprod.111.096198

Vancouver

Stanley JL, Andersson IJ, Hirt CJ, Moore L, Dilworth MR, Chade AR et al. Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction. Biology of reproduction. 2012 Jul;87(1):25. https://doi.org/10.1095/biolreprod.111.096198

Author

Stanley, Joanna L. ; Andersson, Irene J. ; Hirt, Cassandra J. ; Moore, Linn ; Dilworth, Mark R. ; Chade, Alejandro R. ; Sibley, Colin P. ; Davidge, Sandra T. ; Baker, Philip N. / Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction. In: Biology of reproduction. 2012 ; Vol. 87, No. 1. pp. 25.

Bibtex

@article{37c645e9347849a385431288a07a314f,
title = "Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction",
abstract = "Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality and is associated with increased uterine artery resistance and levels of oxidative stress. There are currently no available treatments for this condition. The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3-/-). Pregnant Nos3-/- and control C57BL/6J mice were treated with the superoxide dismutase-mimetic Tempol (1 mmol/L) or vehicle from Gestational Day 12.5 to 18.5. Tempol treatment significantly increased pup weight (P",
keywords = "Intrauterine growth restriction, Nitric oxide, Oxidative stress, Placental transport, Pregnancy",
author = "Stanley, {Joanna L.} and Andersson, {Irene J.} and Hirt, {Cassandra J.} and Linn Moore and Dilworth, {Mark R.} and Chade, {Alejandro R.} and Sibley, {Colin P.} and Davidge, {Sandra T.} and Baker, {Philip N.}",
note = "Stanley, Joanna L Andersson, Irene J Hirt, Cassandra J Moore, Linn Dilworth, Mark R Chade, Alejandro R Sibley, Colin P Davidge, Sandra T Baker, Philip N HL095638/HL/NHLBI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Biology of reproduction Biol Reprod. 2012 Jul 26;87(1):25, 1-8. Print 2012 Jul.",
year = "2012",
month = "7",
doi = "10.1095/biolreprod.111.096198",
language = "English",
volume = "87",
pages = "25",
journal = "Biology of reproduction",
issn = "0006-3363",
publisher = "Society for the Study of Reproduction",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction

AU - Stanley, Joanna L.

AU - Andersson, Irene J.

AU - Hirt, Cassandra J.

AU - Moore, Linn

AU - Dilworth, Mark R.

AU - Chade, Alejandro R.

AU - Sibley, Colin P.

AU - Davidge, Sandra T.

AU - Baker, Philip N.

N1 - Stanley, Joanna L Andersson, Irene J Hirt, Cassandra J Moore, Linn Dilworth, Mark R Chade, Alejandro R Sibley, Colin P Davidge, Sandra T Baker, Philip N HL095638/HL/NHLBI NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Biology of reproduction Biol Reprod. 2012 Jul 26;87(1):25, 1-8. Print 2012 Jul.

PY - 2012/7

Y1 - 2012/7

N2 - Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality and is associated with increased uterine artery resistance and levels of oxidative stress. There are currently no available treatments for this condition. The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3-/-). Pregnant Nos3-/- and control C57BL/6J mice were treated with the superoxide dismutase-mimetic Tempol (1 mmol/L) or vehicle from Gestational Day 12.5 to 18.5. Tempol treatment significantly increased pup weight (P

AB - Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality and is associated with increased uterine artery resistance and levels of oxidative stress. There are currently no available treatments for this condition. The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3-/-). Pregnant Nos3-/- and control C57BL/6J mice were treated with the superoxide dismutase-mimetic Tempol (1 mmol/L) or vehicle from Gestational Day 12.5 to 18.5. Tempol treatment significantly increased pup weight (P

KW - Intrauterine growth restriction

KW - Nitric oxide

KW - Oxidative stress

KW - Placental transport

KW - Pregnancy

U2 - 10.1095/biolreprod.111.096198

DO - 10.1095/biolreprod.111.096198

M3 - Article

VL - 87

SP - 25

JO - Biology of reproduction

JF - Biology of reproduction

SN - 0006-3363

IS - 1

ER -