Effect of the anti-oxidant tempol on fetal growth in a mouse model of fetal growth restriction

Research output: Contribution to journalArticle

  • External authors:
  • Joanna L. Stanley
  • Irene J. Andersson
  • Cassandra J. Hirt
  • Linn Moore
  • Alejandro R. Chade
  • Sandra T. Davidge
  • Philip N. Baker

Abstract

Fetal growth restriction (FGR) greatly increases the risk of perinatal morbidity and mortality and is associated with increased uterine artery resistance and levels of oxidative stress. There are currently no available treatments for this condition. The hypothesis that the antioxidant 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol) would improve uterine artery function and rescue fetal growth was tested in a mouse model of FGR, using the endothelial nitric oxide synthase knockout mouse (Nos3-/-). Pregnant Nos3-/- and control C57BL/6J mice were treated with the superoxide dismutase-mimetic Tempol (1 mmol/L) or vehicle from Gestational Day 12.5 to 18.5. Tempol treatment significantly increased pup weight (P

Bibliographical metadata

Original languageEnglish
Pages (from-to)25
JournalBiology of reproduction
Volume87
Issue number1
DOIs
Publication statusPublished - Jul 2012