Dysphagia in early stage Huntington’s disease (HD) – Pilot observations from a multimodal imaging study

Research output: Contribution to journalMeeting Abstract

  • External authors:
  • I Trender-Gerhard
  • A Gerhard
  • S Handy

Abstract

Introduction: Dysphagia is present in early stage Huntington's Disease (HD) and worsens with disease progression; resulting in weight loss, aspiration pneumonia and often death. The underlying mechanisms for oropharyngeal dysphagia in HD are not well understood. Here, we assess the central neural control of swallowing in HD patients with mild dysphagia combining fluoroscopic swallowing assessments with functional [18F]fluorodeoxyglucose Positron Emission Tomography (FDG PET). Methods: Patients with a clinical diagnosis of Huntington's disease stage I-II were approached. Only patients with mild dysphagia, based on clinical assessments, videofluoroscopy (VFS) and questionnaires, were eligible. In the pilot phase of the study, we analysed the data of 7 study participants - 3 patients with early stage HD (2 male) and 4 age-matched healthy controls. Each was assessed in a randomised, cross-over 2 scan paradigm of resting condition vs water swallowing at 20-second intervals both for 20 minutes prior to PET scanning. Motion correction was applied to correct for involuntary movements. In order to compare the differences between patients and healthy controls, we calculated the scaled differences in activation during swallowing. Results: All patients presented mild swallow impairments, with an increase in pharyngeal delay time and penetration scores in liquid swallows on VFS. In contrast to controls, the patients showed relative deactivation of the frontal cortex compared to other brain regions at rest and during swallowing tasks (Figure 1) and pronounced activation in precentral cortex and anterior cingulate superior areas. Conclusions: There are differences in brain activation patterns between early stage dysphagic HD patients and healthy controls. Frontal cortex deactivation during swallowing in HD may be due to defects of the basal ganglia-thalamocortical projections, with over-compensation for swallowing (motor cortex activation). Further analysis of the dataset will allow more definitive findings in this complex neurogenic condition. (Figure Presented).

Bibliographical metadata

Original languageEnglish
Pages (from-to)http://www.mdsabstracts.org/abstract/dysphagia-in-
JournalGastroenterology
Volume31
Issue number2
Publication statusPublished - 1 Jun 2016