Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion

Research output: Contribution to journalArticle

  • External authors:
  • Lara Lacerda
  • Anuradha Soundararajan
  • Ravi Singh
  • Giorgia Pastorin
  • Khuloud T. Al-Jamal
  • John Turton
  • Peter Frederik
  • Maria A. Herrero
  • Shouping Li
  • Ande Bao
  • Dimitris Emfietzoglou
  • Stephen Mather
  • William T. Phillips
  • Maurizio Prato
  • Alberto Bianco
  • Beth Goins

Abstract

Multi-walled carbon nanotubes functionalized with diethylentriaminepentaacetic dianhydride (DTPA-MWNT) and radiolabeled with Indium-111, having therapeutic and diagnostic applications, were tracked in the systemic blood circulation and the excretory system using a microSingle Photon Emission Tomography (microSPECT) scanner. Quantitative Kaiser test was used to determine the number of free amino groups on the DTPA-MWNT. A suspension of PBS and DTPA-MWNT was intravenously injected by tail vein in the Wistar rats and the urine production, water consumption and body weight were observed for 24 hours. The rat was necropised and tissues of various organs were fixed and observed with a Nikon Microphot-FXA microscope coupled with digital camera. The Length of DTPA-MWNT used in the study is larger than the dimensions of the glomerular capillary wall, so it was excreted through urine after 24 hours post-administration.

Bibliographical metadata

Original languageEnglish
Pages (from-to)225-230
Number of pages5
JournalAdvanced Materials
Volume20
Issue number2
DOIs
Publication statusPublished - 18 Jan 2008