Dual-echo fMRI can detect activations in inferior temporal lobe during intelligible speech comprehensionCitation formats

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Dual-echo fMRI can detect activations in inferior temporal lobe during intelligible speech comprehension. / Halai, Ajay; Parkes, Laura; Welbourne, Stephen.

In: NeuroImage, Vol. 122, 11.2015, p. 214-221.

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@article{93a52fb991ff4bc0b38fa810de62c0e7,
title = "Dual-echo fMRI can detect activations in inferior temporal lobe during intelligible speech comprehension",
abstract = "The neural basis of speech comprehension has been investigated intensively during the past few decades. Incoming auditory signals are analysed for speech-like patterns and meaningful information can be extracted by mapping these sounds onto stored semantic representations. Investigation into the neural basis of speech comprehension has largely focused on the temporal lobe, in particular the superior and posterior regions. The ventral anterior temporal lobe (vATL), which includes the inferior temporal gyrus (ITG) and temporal fusiform gyrus (TFG) is consistently omitted in fMRI studies. In contrast, PET studies have shown the involvement of these ventral temporal regions. One crucial factor is the signal loss experienced using conventional echo planar imaging (EPI) for fMRI, at tissue interfaces such as the vATL. One method to overcome this signal loss is to employ a dual-echo EPI technique. The aim of this study was to use intelligible and unintelligible (spectrally rotated) sentences to determine if the vATL could be detected during a passive speech comprehension task using a dual-echo acquisition. A whole brain analysis for an intelligibility contrast showed bilateral superior temporal lobe activations and a cluster of activation within the left vATL. Converging evidence implicates the same ventral temporal regions during semantic processing tasks, which include language processing. The specific role of the ventral temporal region during intelligible speech processing cannot be determined from this data alone, but the converging evidence from PET, MEG, TMS and neuropsychology strongly suggest that it contains the stored semantic representations, which are activated by the speech decoding process.",
keywords = "Dual gradient-echo, Inferior temporal lobe, Intelligible speech, Magnetic susceptibility",
author = "Ajay Halai and Laura Parkes and Stephen Welbourne",
year = "2015",
month = "11",
doi = "10.1016/j.neuroimage.2015.05.067",
language = "English",
volume = "122",
pages = "214--221",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Dual-echo fMRI can detect activations in inferior temporal lobe during intelligible speech comprehension

AU - Halai, Ajay

AU - Parkes, Laura

AU - Welbourne, Stephen

PY - 2015/11

Y1 - 2015/11

N2 - The neural basis of speech comprehension has been investigated intensively during the past few decades. Incoming auditory signals are analysed for speech-like patterns and meaningful information can be extracted by mapping these sounds onto stored semantic representations. Investigation into the neural basis of speech comprehension has largely focused on the temporal lobe, in particular the superior and posterior regions. The ventral anterior temporal lobe (vATL), which includes the inferior temporal gyrus (ITG) and temporal fusiform gyrus (TFG) is consistently omitted in fMRI studies. In contrast, PET studies have shown the involvement of these ventral temporal regions. One crucial factor is the signal loss experienced using conventional echo planar imaging (EPI) for fMRI, at tissue interfaces such as the vATL. One method to overcome this signal loss is to employ a dual-echo EPI technique. The aim of this study was to use intelligible and unintelligible (spectrally rotated) sentences to determine if the vATL could be detected during a passive speech comprehension task using a dual-echo acquisition. A whole brain analysis for an intelligibility contrast showed bilateral superior temporal lobe activations and a cluster of activation within the left vATL. Converging evidence implicates the same ventral temporal regions during semantic processing tasks, which include language processing. The specific role of the ventral temporal region during intelligible speech processing cannot be determined from this data alone, but the converging evidence from PET, MEG, TMS and neuropsychology strongly suggest that it contains the stored semantic representations, which are activated by the speech decoding process.

AB - The neural basis of speech comprehension has been investigated intensively during the past few decades. Incoming auditory signals are analysed for speech-like patterns and meaningful information can be extracted by mapping these sounds onto stored semantic representations. Investigation into the neural basis of speech comprehension has largely focused on the temporal lobe, in particular the superior and posterior regions. The ventral anterior temporal lobe (vATL), which includes the inferior temporal gyrus (ITG) and temporal fusiform gyrus (TFG) is consistently omitted in fMRI studies. In contrast, PET studies have shown the involvement of these ventral temporal regions. One crucial factor is the signal loss experienced using conventional echo planar imaging (EPI) for fMRI, at tissue interfaces such as the vATL. One method to overcome this signal loss is to employ a dual-echo EPI technique. The aim of this study was to use intelligible and unintelligible (spectrally rotated) sentences to determine if the vATL could be detected during a passive speech comprehension task using a dual-echo acquisition. A whole brain analysis for an intelligibility contrast showed bilateral superior temporal lobe activations and a cluster of activation within the left vATL. Converging evidence implicates the same ventral temporal regions during semantic processing tasks, which include language processing. The specific role of the ventral temporal region during intelligible speech processing cannot be determined from this data alone, but the converging evidence from PET, MEG, TMS and neuropsychology strongly suggest that it contains the stored semantic representations, which are activated by the speech decoding process.

KW - Dual gradient-echo

KW - Inferior temporal lobe

KW - Intelligible speech

KW - Magnetic susceptibility

U2 - 10.1016/j.neuroimage.2015.05.067

DO - 10.1016/j.neuroimage.2015.05.067

M3 - Article

VL - 122

SP - 214

EP - 221

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -