Drug targeting of heme proteins in Mycobacterium tuberculosis

Research output: Contribution to journalReview article

Abstract

TB, caused by the human pathogen Mycobacterium tuberculosis (Mtb), causes more deaths than any other infectious disease. Iron is crucial for Mtb to infect the host and to sustain infection, with Mtb encoding large numbers of iron-binding proteins. Many of these are hemoproteins with key roles, including defense against oxidative stress, cellular signaling and regulation, host cholesterol metabolism, and respiratory processes. Various heme enzymes in Mtb are validated drug targets and/or products of genes essential for bacterial viability or survival in the host. Here, we review the structure, function, and druggability of key Mtb heme enzymes and strategies used for their inhibition.

Bibliographical metadata

Original languageEnglish
Pages (from-to)566-575
Number of pages10
JournalDrug Discovery Today
Volume22
Issue number3
Early online date14 Nov 2016
DOIs
StatePublished - 22 Mar 2017