Does the age of pharmaceuticals matter? Undetectable hydrate seeds impact hydration behaviour

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Abstract

A study on the hydration behaviour of fluconazole demonstrates that both sample age and polymorphic form impacted the drugs kinetic stability to hydration. For two of the polymorphs, aged samples were found to hydrate more readily than fresh samples. The aging effect was attributed to the formation of monohydrate (MH) crystals over time. The MH, despite being initially undetectable, had a seeding effect, thus impacting the hydration kinetics.

Bibliographical metadata

Original languageEnglish
JournalCrystal Growth & Design
Publication statusAccepted/In press - 17 Mar 2021