Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradianceCitation formats

  • External authors:
  • Gurprit S. Lall
  • Victoria L. Revell
  • Hiroshi Momiji
  • Jazi Al Enezi
  • Cara M. Altimus
  • Ali D. Güler
  • Carlos Aguilar
  • Morven A. Cameron
  • Susan Allender
  • Mark W. Hankins

Standard

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. / Lall, Gurprit S.; Revell, Victoria L.; Momiji, Hiroshi; Al Enezi, Jazi; Altimus, Cara M.; Güler, Ali D.; Aguilar, Carlos; Cameron, Morven A.; Allender, Susan; Hankins, Mark W.; Lucas, Robert J.

In: Neuron, Vol. 66, No. 3, 05.2010, p. 417-428.

Research output: Contribution to journalArticlepeer-review

Harvard

Lall, GS, Revell, VL, Momiji, H, Al Enezi, J, Altimus, CM, Güler, AD, Aguilar, C, Cameron, MA, Allender, S, Hankins, MW & Lucas, RJ 2010, 'Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance', Neuron, vol. 66, no. 3, pp. 417-428. https://doi.org/10.1016/j.neuron.2010.04.037

APA

Lall, G. S., Revell, V. L., Momiji, H., Al Enezi, J., Altimus, C. M., Güler, A. D., Aguilar, C., Cameron, M. A., Allender, S., Hankins, M. W., & Lucas, R. J. (2010). Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. Neuron, 66(3), 417-428. https://doi.org/10.1016/j.neuron.2010.04.037

Vancouver

Lall GS, Revell VL, Momiji H, Al Enezi J, Altimus CM, Güler AD et al. Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. Neuron. 2010 May;66(3):417-428. https://doi.org/10.1016/j.neuron.2010.04.037

Author

Lall, Gurprit S. ; Revell, Victoria L. ; Momiji, Hiroshi ; Al Enezi, Jazi ; Altimus, Cara M. ; Güler, Ali D. ; Aguilar, Carlos ; Cameron, Morven A. ; Allender, Susan ; Hankins, Mark W. ; Lucas, Robert J. / Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. In: Neuron. 2010 ; Vol. 66, No. 3. pp. 417-428.

Bibtex

@article{3a6a023b14554b5f8fc3a883da2aff6f,
title = "Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance",
abstract = "Photoreceptive, melanopsin-expressing retinal ganglion cells (mRGCs) encode ambient light (irradiance) for the circadian clock, the pupillomotor system, and other influential behavioral/physiological responses. mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones. However, the individual contribution of each photoreceptor class to irradiance responses remains unclear. We address this deficit using mice expressing human red cone opsin, in which rod-, cone-, and melanopsin-dependent responses can be identified by their distinct spectral sensitivity. Our data reveal an unexpectedly important role for rods. These photoreceptors define circadian responses at very dim {"} scotopic{"} light levels but also at irradiances at which pattern vision relies heavily on cones. By contrast, cone input to irradiance responses dissipates following light adaptation to the extent that these receptors make a very limited contribution to circadian and pupillary light responses under these conditions. Our data provide new insight into retinal circuitry upstream of mRGCs and optimal stimuli for eliciting irradiance responses. {\textcopyright} 2010 Elsevier Inc.",
keywords = "CELLBIO, SYSNEURO",
author = "Lall, {Gurprit S.} and Revell, {Victoria L.} and Hiroshi Momiji and {Al Enezi}, Jazi and Altimus, {Cara M.} and G{\"u}ler, {Ali D.} and Carlos Aguilar and Cameron, {Morven A.} and Susan Allender and Hankins, {Mark W.} and Lucas, {Robert J.}",
note = ", Biotechnology and Biological Sciences Research Council, United Kingdom, Wellcome Trust, United Kingdom",
year = "2010",
month = may,
doi = "10.1016/j.neuron.2010.04.037",
language = "English",
volume = "66",
pages = "417--428",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance

AU - Lall, Gurprit S.

AU - Revell, Victoria L.

AU - Momiji, Hiroshi

AU - Al Enezi, Jazi

AU - Altimus, Cara M.

AU - Güler, Ali D.

AU - Aguilar, Carlos

AU - Cameron, Morven A.

AU - Allender, Susan

AU - Hankins, Mark W.

AU - Lucas, Robert J.

N1 - , Biotechnology and Biological Sciences Research Council, United Kingdom, Wellcome Trust, United Kingdom

PY - 2010/5

Y1 - 2010/5

N2 - Photoreceptive, melanopsin-expressing retinal ganglion cells (mRGCs) encode ambient light (irradiance) for the circadian clock, the pupillomotor system, and other influential behavioral/physiological responses. mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones. However, the individual contribution of each photoreceptor class to irradiance responses remains unclear. We address this deficit using mice expressing human red cone opsin, in which rod-, cone-, and melanopsin-dependent responses can be identified by their distinct spectral sensitivity. Our data reveal an unexpectedly important role for rods. These photoreceptors define circadian responses at very dim " scotopic" light levels but also at irradiances at which pattern vision relies heavily on cones. By contrast, cone input to irradiance responses dissipates following light adaptation to the extent that these receptors make a very limited contribution to circadian and pupillary light responses under these conditions. Our data provide new insight into retinal circuitry upstream of mRGCs and optimal stimuli for eliciting irradiance responses. © 2010 Elsevier Inc.

AB - Photoreceptive, melanopsin-expressing retinal ganglion cells (mRGCs) encode ambient light (irradiance) for the circadian clock, the pupillomotor system, and other influential behavioral/physiological responses. mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones. However, the individual contribution of each photoreceptor class to irradiance responses remains unclear. We address this deficit using mice expressing human red cone opsin, in which rod-, cone-, and melanopsin-dependent responses can be identified by their distinct spectral sensitivity. Our data reveal an unexpectedly important role for rods. These photoreceptors define circadian responses at very dim " scotopic" light levels but also at irradiances at which pattern vision relies heavily on cones. By contrast, cone input to irradiance responses dissipates following light adaptation to the extent that these receptors make a very limited contribution to circadian and pupillary light responses under these conditions. Our data provide new insight into retinal circuitry upstream of mRGCs and optimal stimuli for eliciting irradiance responses. © 2010 Elsevier Inc.

KW - CELLBIO

KW - SYSNEURO

U2 - 10.1016/j.neuron.2010.04.037

DO - 10.1016/j.neuron.2010.04.037

M3 - Article

C2 - 20471354

VL - 66

SP - 417

EP - 428

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -