Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Gurprit S. Lall
  • Victoria L. Revell
  • Hiroshi Momiji
  • Jazi Al Enezi
  • Cara M. Altimus
  • Ali D. Güler
  • Carlos Aguilar
  • Morven A. Cameron
  • Susan Allender
  • Mark W. Hankins

Abstract

Photoreceptive, melanopsin-expressing retinal ganglion cells (mRGCs) encode ambient light (irradiance) for the circadian clock, the pupillomotor system, and other influential behavioral/physiological responses. mRGCs are activated both by their intrinsic phototransduction cascade and by the rods and cones. However, the individual contribution of each photoreceptor class to irradiance responses remains unclear. We address this deficit using mice expressing human red cone opsin, in which rod-, cone-, and melanopsin-dependent responses can be identified by their distinct spectral sensitivity. Our data reveal an unexpectedly important role for rods. These photoreceptors define circadian responses at very dim " scotopic" light levels but also at irradiances at which pattern vision relies heavily on cones. By contrast, cone input to irradiance responses dissipates following light adaptation to the extent that these receptors make a very limited contribution to circadian and pupillary light responses under these conditions. Our data provide new insight into retinal circuitry upstream of mRGCs and optimal stimuli for eliciting irradiance responses. © 2010 Elsevier Inc.

Bibliographical metadata

Original languageEnglish
Pages (from-to)417-428
Number of pages11
JournalNeuron
Volume66
Issue number3
DOIs
Publication statusPublished - May 2010

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