Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infectionCitation formats

  • External authors:
  • Callum Thorpe
  • Lorna Edwards
  • Robert Snelgrove
  • Oretta Finco
  • Aaron Rae
  • Guido Grandi
  • Ratti Guilio

Standard

Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection. / Thorpe, Callum; Edwards, Lorna; Snelgrove, Robert; Finco, Oretta; Rae, Aaron; Grandi, Guido; Guilio, Ratti; Hussell, Tracy.

In: Vaccine, Vol. 25, No. 12, 08.03.2007, p. 2252-2260.

Research output: Contribution to journalArticlepeer-review

Harvard

Thorpe, C, Edwards, L, Snelgrove, R, Finco, O, Rae, A, Grandi, G, Guilio, R & Hussell, T 2007, 'Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection', Vaccine, vol. 25, no. 12, pp. 2252-2260. https://doi.org/10.1016/j.vaccine.2006.12.003

APA

Thorpe, C., Edwards, L., Snelgrove, R., Finco, O., Rae, A., Grandi, G., Guilio, R., & Hussell, T. (2007). Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection. Vaccine, 25(12), 2252-2260. https://doi.org/10.1016/j.vaccine.2006.12.003

Vancouver

Thorpe C, Edwards L, Snelgrove R, Finco O, Rae A, Grandi G et al. Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection. Vaccine. 2007 Mar 8;25(12):2252-2260. https://doi.org/10.1016/j.vaccine.2006.12.003

Author

Thorpe, Callum ; Edwards, Lorna ; Snelgrove, Robert ; Finco, Oretta ; Rae, Aaron ; Grandi, Guido ; Guilio, Ratti ; Hussell, Tracy. / Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection. In: Vaccine. 2007 ; Vol. 25, No. 12. pp. 2252-2260.

Bibtex

@article{43d089a1f03942508f9b6c0689674ae7,
title = "Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection",
abstract = "Chlamydiae are atypical intracellular bacteria that infect via mucosal surfaces causing, for example, trachoma, pneumonia, cervicitis, urethritis and infertility. Existing antibiotics are only partially effective and no vaccines are available. Using surface expressed or secreted proteins previously identified by genomics and proteomics we tested five as vaccines against intranasal challenge with Chlamydia pneumoniae. One antigen, LcrE, induced CD4+ and CD8+ T cell activation, type 1 cytokine secretion and neutralising antibodies and was completely effective in eliminating infection. Such antigens are highly conserved and essential to all Chlamydial species. The discovery of an effective vaccine for Chlamydiae pneumoniae has potential wide benefits for human health. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",
keywords = "Chlamydia, Protection, Vaccine",
author = "Callum Thorpe and Lorna Edwards and Robert Snelgrove and Oretta Finco and Aaron Rae and Guido Grandi and Ratti Guilio and Tracy Hussell",
year = "2007",
month = mar,
day = "8",
doi = "10.1016/j.vaccine.2006.12.003",
language = "English",
volume = "25",
pages = "2252--2260",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "12",

}

RIS

TY - JOUR

T1 - Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection

AU - Thorpe, Callum

AU - Edwards, Lorna

AU - Snelgrove, Robert

AU - Finco, Oretta

AU - Rae, Aaron

AU - Grandi, Guido

AU - Guilio, Ratti

AU - Hussell, Tracy

PY - 2007/3/8

Y1 - 2007/3/8

N2 - Chlamydiae are atypical intracellular bacteria that infect via mucosal surfaces causing, for example, trachoma, pneumonia, cervicitis, urethritis and infertility. Existing antibiotics are only partially effective and no vaccines are available. Using surface expressed or secreted proteins previously identified by genomics and proteomics we tested five as vaccines against intranasal challenge with Chlamydia pneumoniae. One antigen, LcrE, induced CD4+ and CD8+ T cell activation, type 1 cytokine secretion and neutralising antibodies and was completely effective in eliminating infection. Such antigens are highly conserved and essential to all Chlamydial species. The discovery of an effective vaccine for Chlamydiae pneumoniae has potential wide benefits for human health. © 2006 Elsevier Ltd. All rights reserved.

AB - Chlamydiae are atypical intracellular bacteria that infect via mucosal surfaces causing, for example, trachoma, pneumonia, cervicitis, urethritis and infertility. Existing antibiotics are only partially effective and no vaccines are available. Using surface expressed or secreted proteins previously identified by genomics and proteomics we tested five as vaccines against intranasal challenge with Chlamydia pneumoniae. One antigen, LcrE, induced CD4+ and CD8+ T cell activation, type 1 cytokine secretion and neutralising antibodies and was completely effective in eliminating infection. Such antigens are highly conserved and essential to all Chlamydial species. The discovery of an effective vaccine for Chlamydiae pneumoniae has potential wide benefits for human health. © 2006 Elsevier Ltd. All rights reserved.

KW - Chlamydia

KW - Protection

KW - Vaccine

U2 - 10.1016/j.vaccine.2006.12.003

DO - 10.1016/j.vaccine.2006.12.003

M3 - Article

C2 - 17275142

VL - 25

SP - 2252

EP - 2260

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 12

ER -