Discovery of a vaccine antigen that protects mice from Chlamydia pneumoniae infection

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Callum Thorpe
  • Lorna Edwards
  • Robert Snelgrove
  • Oretta Finco
  • Aaron Rae
  • Guido Grandi
  • Ratti Guilio

Abstract

Chlamydiae are atypical intracellular bacteria that infect via mucosal surfaces causing, for example, trachoma, pneumonia, cervicitis, urethritis and infertility. Existing antibiotics are only partially effective and no vaccines are available. Using surface expressed or secreted proteins previously identified by genomics and proteomics we tested five as vaccines against intranasal challenge with Chlamydia pneumoniae. One antigen, LcrE, induced CD4+ and CD8+ T cell activation, type 1 cytokine secretion and neutralising antibodies and was completely effective in eliminating infection. Such antigens are highly conserved and essential to all Chlamydial species. The discovery of an effective vaccine for Chlamydiae pneumoniae has potential wide benefits for human health. © 2006 Elsevier Ltd. All rights reserved.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2252-2260
Number of pages8
JournalVaccine
Volume25
Issue number12
DOIs
Publication statusPublished - 8 Mar 2007