Direct arylation of oxazoles at C2. A concise approach to consecutively linked oxazoles.

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Abstract

The synthesis of bis- and trisoxazoles via direct arylation is discussed. A variety of aryl groups can be installed at the 2-position of 5-aryl and 5-carboxy-substituted oxazoles under mild conditions using palladium catalysis on water. The direct arylation method can be extended to the synthesis of bis- and trisoxazoles if 2-triisopropylsilyl-4-iodooxazole is used as the electrophile in the arylation.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2717-2720
Number of pages3
JournalOrganic Letters
Volume10
Issue number13
DOIs
StatePublished - 3 Jul 2008