Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Research output: Research - peer-reviewLetter

  • External authors:
  • Aleksander M Grabiec
  • Nicholas Denny
  • John Doherty
  • Kaisa E Happonen
  • Emma Connolly
  • Mark E Fife
  • Toshifumi Fujimori
  • Naoya Fujino
  • Susan Holden
  • Gael Gioan-Tavernier
  • Rajesh Shah
  • Björn Dahlbäck
  • Angela Simpson
  • Tracy Hussell

Abstract

The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance

Bibliographical metadata

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Early online date12 Apr 2017
DOIs
StateE-pub ahead of print - 12 Apr 2017