Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

Research output: Contribution to journalArticle

  • Authors:
  • Vincent Diemer
  • Julien Maury
  • Bryden Le Bailly
  • Simon Webb
  • Jonathan Clayden

Abstract

Conformationally mobile oligomers with helical structures, or 'dynamic foldamers', may populate a mixture of screw sense conformers whose relative proportion has been used as a means of communicating information on a molecular scale. The dibenzazepinyl urea provides a means of quantifying both the sense and degree of this screw sense preference through a combination of circular dichroism and NMR spectroscopy. The dibenzazepinyl urea probe is synthetically versatile, readily accessible, and easy to introduce to the terminus of an amide or a urea foldamer.

Bibliographical metadata

Original languageEnglish
JournalChemical Communications
Early online date31 Aug 2017
DOIs
Publication statusPublished - 2017