Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapyCitation formats

  • External authors:
  • Damian J J Farnell
  • Paula Mandall
  • Carmel Anandadas
  • Jaqueline Routledge
  • Meriel P. Burns
  • John P. Logue
  • James P. Wylie
  • Ric Swindell
  • Jac Livsey
  • Susan E. Davidson

Standard

Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy. / Farnell, Damian J J; Mandall, Paula; Anandadas, Carmel; Routledge, Jaqueline; Burns, Meriel P.; Logue, John P.; Wylie, James P.; Swindell, Ric; Livsey, Jac; West, Catharine M L; Davidson, Susan E.

In: Radiotherapy and Oncology, Vol. 97, No. 1, 10.2010, p. 136-142.

Research output: Contribution to journalArticlepeer-review

Harvard

Farnell, DJJ, Mandall, P, Anandadas, C, Routledge, J, Burns, MP, Logue, JP, Wylie, JP, Swindell, R, Livsey, J, West, CML & Davidson, SE 2010, 'Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy', Radiotherapy and Oncology, vol. 97, no. 1, pp. 136-142. https://doi.org/10.1016/j.radonc.2010.05.011

APA

Farnell, D. J. J., Mandall, P., Anandadas, C., Routledge, J., Burns, M. P., Logue, J. P., Wylie, J. P., Swindell, R., Livsey, J., West, C. M. L., & Davidson, S. E. (2010). Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy. Radiotherapy and Oncology, 97(1), 136-142. https://doi.org/10.1016/j.radonc.2010.05.011

Vancouver

Farnell DJJ, Mandall P, Anandadas C, Routledge J, Burns MP, Logue JP et al. Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy. Radiotherapy and Oncology. 2010 Oct;97(1):136-142. https://doi.org/10.1016/j.radonc.2010.05.011

Author

Farnell, Damian J J ; Mandall, Paula ; Anandadas, Carmel ; Routledge, Jaqueline ; Burns, Meriel P. ; Logue, John P. ; Wylie, James P. ; Swindell, Ric ; Livsey, Jac ; West, Catharine M L ; Davidson, Susan E. / Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy. In: Radiotherapy and Oncology. 2010 ; Vol. 97, No. 1. pp. 136-142.

Bibtex

@article{0ad50bf7412940aba514e80961db9a83,
title = "Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy",
abstract = "Purpose: To improve a questionnaire used to collect patient-reported outcomes from patients with early stage prostate cancer treated with brachytherapy. A secondary aim was to adapt the Late Effects of Normal Tissue (LENT) subjective toxicity questionnaire for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data, the current preferred platform for assessing radiation toxicity. Materials and methods: Three hundred and seventy-seven patients were treated with permanent iodine-125 seed implant brachytherapy for early prostate cancer. Toxicity data were collected before and at nine time points post-treatment (0-36 months). Compliance rates for patients completing individual items and item-subsection correlation coefficients were calculated. A factor analysis was carried out to analyse responses to the questionnaire and identify less informative questions, which could be removed. Cronbach's α coefficient was used to measure reliability. Results: Two thousand one hundred and eighty-eight questionnaires were analysed. There was poor compliance for questions specifically relating to operations and bowel medication. We found that the division of the questionnaire into subsections based on anatomical site was reasonable and that certain items could be safely removed. The high mean value for Cronbach's α across all questionnaires (0.752; 95% CI: 0.726-0.779) indicated that the questionnaire was reliable. Fifteen of the 44 questions were removed from the original questionnaires. Questions on urinary incontinence severity, management of urinary and bowel incontinence, effects of reduced flow of urine and the effects of symptoms on activity of daily living and change in sexual function were required to adapt the LENT subjective questionnaire for use to collect CTCAE data. Conclusions: A questionnaire, validated over 6 years to collect LENT subjective data were adapted and is a reliable approach for collecting CTCAE data after prostate brachytherapy. {\textcopyright} 2010 Elsevier Ireland Ltd. All rights reserved.",
keywords = "CTCAE, LENT, Normal tissue, Patient-reported outcomes, Prostate cancer, Toxicity",
author = "Farnell, {Damian J J} and Paula Mandall and Carmel Anandadas and Jaqueline Routledge and Burns, {Meriel P.} and Logue, {John P.} and Wylie, {James P.} and Ric Swindell and Jac Livsey and West, {Catharine M L} and Davidson, {Susan E.}",
year = "2010",
month = oct,
doi = "10.1016/j.radonc.2010.05.011",
language = "English",
volume = "97",
pages = "136--142",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy

AU - Farnell, Damian J J

AU - Mandall, Paula

AU - Anandadas, Carmel

AU - Routledge, Jaqueline

AU - Burns, Meriel P.

AU - Logue, John P.

AU - Wylie, James P.

AU - Swindell, Ric

AU - Livsey, Jac

AU - West, Catharine M L

AU - Davidson, Susan E.

PY - 2010/10

Y1 - 2010/10

N2 - Purpose: To improve a questionnaire used to collect patient-reported outcomes from patients with early stage prostate cancer treated with brachytherapy. A secondary aim was to adapt the Late Effects of Normal Tissue (LENT) subjective toxicity questionnaire for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data, the current preferred platform for assessing radiation toxicity. Materials and methods: Three hundred and seventy-seven patients were treated with permanent iodine-125 seed implant brachytherapy for early prostate cancer. Toxicity data were collected before and at nine time points post-treatment (0-36 months). Compliance rates for patients completing individual items and item-subsection correlation coefficients were calculated. A factor analysis was carried out to analyse responses to the questionnaire and identify less informative questions, which could be removed. Cronbach's α coefficient was used to measure reliability. Results: Two thousand one hundred and eighty-eight questionnaires were analysed. There was poor compliance for questions specifically relating to operations and bowel medication. We found that the division of the questionnaire into subsections based on anatomical site was reasonable and that certain items could be safely removed. The high mean value for Cronbach's α across all questionnaires (0.752; 95% CI: 0.726-0.779) indicated that the questionnaire was reliable. Fifteen of the 44 questions were removed from the original questionnaires. Questions on urinary incontinence severity, management of urinary and bowel incontinence, effects of reduced flow of urine and the effects of symptoms on activity of daily living and change in sexual function were required to adapt the LENT subjective questionnaire for use to collect CTCAE data. Conclusions: A questionnaire, validated over 6 years to collect LENT subjective data were adapted and is a reliable approach for collecting CTCAE data after prostate brachytherapy. © 2010 Elsevier Ireland Ltd. All rights reserved.

AB - Purpose: To improve a questionnaire used to collect patient-reported outcomes from patients with early stage prostate cancer treated with brachytherapy. A secondary aim was to adapt the Late Effects of Normal Tissue (LENT) subjective toxicity questionnaire for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data, the current preferred platform for assessing radiation toxicity. Materials and methods: Three hundred and seventy-seven patients were treated with permanent iodine-125 seed implant brachytherapy for early prostate cancer. Toxicity data were collected before and at nine time points post-treatment (0-36 months). Compliance rates for patients completing individual items and item-subsection correlation coefficients were calculated. A factor analysis was carried out to analyse responses to the questionnaire and identify less informative questions, which could be removed. Cronbach's α coefficient was used to measure reliability. Results: Two thousand one hundred and eighty-eight questionnaires were analysed. There was poor compliance for questions specifically relating to operations and bowel medication. We found that the division of the questionnaire into subsections based on anatomical site was reasonable and that certain items could be safely removed. The high mean value for Cronbach's α across all questionnaires (0.752; 95% CI: 0.726-0.779) indicated that the questionnaire was reliable. Fifteen of the 44 questions were removed from the original questionnaires. Questions on urinary incontinence severity, management of urinary and bowel incontinence, effects of reduced flow of urine and the effects of symptoms on activity of daily living and change in sexual function were required to adapt the LENT subjective questionnaire for use to collect CTCAE data. Conclusions: A questionnaire, validated over 6 years to collect LENT subjective data were adapted and is a reliable approach for collecting CTCAE data after prostate brachytherapy. © 2010 Elsevier Ireland Ltd. All rights reserved.

KW - CTCAE

KW - LENT

KW - Normal tissue

KW - Patient-reported outcomes

KW - Prostate cancer

KW - Toxicity

U2 - 10.1016/j.radonc.2010.05.011

DO - 10.1016/j.radonc.2010.05.011

M3 - Article

C2 - 20561698

VL - 97

SP - 136

EP - 142

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

IS - 1

ER -