Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patientsCitation formats

  • External authors:
  • Ada G T M Egelmeer
  • E. Rios Velazquez
  • Jos M A De Jong
  • Cary Oberije
  • Yasmyne Geussens
  • Sandra Nuyts
  • Bernd Kremer
  • Derek Rietveld
  • C. René Leemans
  • Monique C. De Jong
  • Coen Rasch
  • Frank Hoebers
  • Jarrod Homer
  • Nick Slevin
  • Philippe Lambin

Standard

Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients. / Egelmeer, Ada G T M; Velazquez, E. Rios; De Jong, Jos M A; Oberije, Cary; Geussens, Yasmyne; Nuyts, Sandra; Kremer, Bernd; Rietveld, Derek; René Leemans, C.; De Jong, Monique C.; Rasch, Coen; Hoebers, Frank; Homer, Jarrod; Slevin, Nick; West, Catharine; Lambin, Philippe.

In: Radiotherapy and Oncology, Vol. 100, No. 1, 07.2011, p. 108-115.

Research output: Contribution to journalArticlepeer-review

Harvard

Egelmeer, AGTM, Velazquez, ER, De Jong, JMA, Oberije, C, Geussens, Y, Nuyts, S, Kremer, B, Rietveld, D, René Leemans, C, De Jong, MC, Rasch, C, Hoebers, F, Homer, J, Slevin, N, West, C & Lambin, P 2011, 'Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients', Radiotherapy and Oncology, vol. 100, no. 1, pp. 108-115. https://doi.org/10.1016/j.radonc.2011.06.023

APA

Egelmeer, A. G. T. M., Velazquez, E. R., De Jong, J. M. A., Oberije, C., Geussens, Y., Nuyts, S., Kremer, B., Rietveld, D., René Leemans, C., De Jong, M. C., Rasch, C., Hoebers, F., Homer, J., Slevin, N., West, C., & Lambin, P. (2011). Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients. Radiotherapy and Oncology, 100(1), 108-115. https://doi.org/10.1016/j.radonc.2011.06.023

Vancouver

Author

Egelmeer, Ada G T M ; Velazquez, E. Rios ; De Jong, Jos M A ; Oberije, Cary ; Geussens, Yasmyne ; Nuyts, Sandra ; Kremer, Bernd ; Rietveld, Derek ; René Leemans, C. ; De Jong, Monique C. ; Rasch, Coen ; Hoebers, Frank ; Homer, Jarrod ; Slevin, Nick ; West, Catharine ; Lambin, Philippe. / Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients. In: Radiotherapy and Oncology. 2011 ; Vol. 100, No. 1. pp. 108-115.

Bibtex

@article{81fc85f03e2644a49b624708193bd937,
title = "Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients",
abstract = "Introduction: To advise laryngeal carcinoma patients on the most appropriate form of treatment, a tool to predict survival and local control is needed. Materials and methods: We performed a population-based cohort study on 994 laryngeal carcinoma patients, treated with RT from 1977 until 2008. Two nomograms were developed and validated. Performance of the models is expressed as the Area Under the Curve (AUC). Results: Unfavorable prognostic factors for overall survival were low hemoglobin level, male sex, high T-status, nodal involvement, older age, lower EQD 2T (total radiation dose corrected for fraction dose and overall treatment time), and non-glottic tumor. All factors except tumor location were prognostic for local control. The AUCs were 0.73 for overall survival and 0.67 for local control. External validation of the survival model yielded AUCs of 0.68, 0.74, 0.76 and 0.71 for the Leuven (n = 109), the VU Amsterdam (n = 178), the Manchester (n = 403) and the NKI cohort (n = 205), respectively, while the validation procedure for the local control model resulted in AUCs of 0.70, 0.71, 0.72 and 0.62. The resulting nomograms were made available on the website www.predictcancer.org. Conclusions: For patients with a laryngeal carcinoma treated with RT alone, we have developed visual, easy-to-use nomograms for the prediction of overall survival and primary local control. These models have been successfully validated in four external centers. {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
keywords = "Laryngeal carcinoma, Nomogram, Prediction, Radiotherapy",
author = "Egelmeer, {Ada G T M} and Velazquez, {E. Rios} and {De Jong}, {Jos M A} and Cary Oberije and Yasmyne Geussens and Sandra Nuyts and Bernd Kremer and Derek Rietveld and {Ren{\'e} Leemans}, C. and {De Jong}, {Monique C.} and Coen Rasch and Frank Hoebers and Jarrod Homer and Nick Slevin and Catharine West and Philippe Lambin",
year = "2011",
month = jul,
doi = "10.1016/j.radonc.2011.06.023",
language = "English",
volume = "100",
pages = "108--115",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier BV",
number = "1",

}

RIS

TY - JOUR

T1 - Development and validation of a nomogram for prediction of survival and local control in laryngeal carcinoma patients treated with radiotherapy alone: A cohort study based on 994 patients

AU - Egelmeer, Ada G T M

AU - Velazquez, E. Rios

AU - De Jong, Jos M A

AU - Oberije, Cary

AU - Geussens, Yasmyne

AU - Nuyts, Sandra

AU - Kremer, Bernd

AU - Rietveld, Derek

AU - René Leemans, C.

AU - De Jong, Monique C.

AU - Rasch, Coen

AU - Hoebers, Frank

AU - Homer, Jarrod

AU - Slevin, Nick

AU - West, Catharine

AU - Lambin, Philippe

PY - 2011/7

Y1 - 2011/7

N2 - Introduction: To advise laryngeal carcinoma patients on the most appropriate form of treatment, a tool to predict survival and local control is needed. Materials and methods: We performed a population-based cohort study on 994 laryngeal carcinoma patients, treated with RT from 1977 until 2008. Two nomograms were developed and validated. Performance of the models is expressed as the Area Under the Curve (AUC). Results: Unfavorable prognostic factors for overall survival were low hemoglobin level, male sex, high T-status, nodal involvement, older age, lower EQD 2T (total radiation dose corrected for fraction dose and overall treatment time), and non-glottic tumor. All factors except tumor location were prognostic for local control. The AUCs were 0.73 for overall survival and 0.67 for local control. External validation of the survival model yielded AUCs of 0.68, 0.74, 0.76 and 0.71 for the Leuven (n = 109), the VU Amsterdam (n = 178), the Manchester (n = 403) and the NKI cohort (n = 205), respectively, while the validation procedure for the local control model resulted in AUCs of 0.70, 0.71, 0.72 and 0.62. The resulting nomograms were made available on the website www.predictcancer.org. Conclusions: For patients with a laryngeal carcinoma treated with RT alone, we have developed visual, easy-to-use nomograms for the prediction of overall survival and primary local control. These models have been successfully validated in four external centers. © 2011 Elsevier Ltd. All rights reserved.

AB - Introduction: To advise laryngeal carcinoma patients on the most appropriate form of treatment, a tool to predict survival and local control is needed. Materials and methods: We performed a population-based cohort study on 994 laryngeal carcinoma patients, treated with RT from 1977 until 2008. Two nomograms were developed and validated. Performance of the models is expressed as the Area Under the Curve (AUC). Results: Unfavorable prognostic factors for overall survival were low hemoglobin level, male sex, high T-status, nodal involvement, older age, lower EQD 2T (total radiation dose corrected for fraction dose and overall treatment time), and non-glottic tumor. All factors except tumor location were prognostic for local control. The AUCs were 0.73 for overall survival and 0.67 for local control. External validation of the survival model yielded AUCs of 0.68, 0.74, 0.76 and 0.71 for the Leuven (n = 109), the VU Amsterdam (n = 178), the Manchester (n = 403) and the NKI cohort (n = 205), respectively, while the validation procedure for the local control model resulted in AUCs of 0.70, 0.71, 0.72 and 0.62. The resulting nomograms were made available on the website www.predictcancer.org. Conclusions: For patients with a laryngeal carcinoma treated with RT alone, we have developed visual, easy-to-use nomograms for the prediction of overall survival and primary local control. These models have been successfully validated in four external centers. © 2011 Elsevier Ltd. All rights reserved.

KW - Laryngeal carcinoma

KW - Nomogram

KW - Prediction

KW - Radiotherapy

U2 - 10.1016/j.radonc.2011.06.023

DO - 10.1016/j.radonc.2011.06.023

M3 - Article

VL - 100

SP - 108

EP - 115

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

IS - 1

ER -