Determining the parameter space for effective oxygen depletion for FLASH radiation therapyCitation formats

  • External authors:
  • Matthew Lowe
  • Ranald Mackay
  • Jolyon Hendry

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Determining the parameter space for effective oxygen depletion for FLASH radiation therapy. / Rothwell, Bethany; Kirkby, Norman; Merchant, Mike; Chadwick, Amy; Lowe, Matthew; Mackay, Ranald; Hendry, Jolyon; Kirkby, Karen.

In: Physics in Medicine & Biology, Vol. 66, 055020, 03.02.2021.

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@article{520d8086be3145d0bec0a45c0fd156a4,
title = "Determining the parameter space for effective oxygen depletion for FLASH radiation therapy",
abstract = "There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxygen depletion paradigm of induced radioresistance. An example eight-dimensional parameter space demonstrates the conditions under which radiation may induce sufficient depletion of oxygen for a diffusion-limited hypoxic cellular response. Initial results support experimental evidence that FLASH sparing is only achieved for dose rates on the order of tens of Gy/s or higher, for a sufficiently high dose, and only for tissue that is slightly hypoxic at the time of radiation. We show that the FLASH effect is the result of a number of biological, radiochemical and delivery parameters. Also, the threshold dose for a FLASH effect occurring would be more prominent when the parameterisation was optimised to produce the maximum effect. The model provides a framework for further FLASH-related investigation and experimental design. An understanding of the mechanistic interactions producing an optimised FLASH effect is essential for its translation into clinical practice.",
author = "Bethany Rothwell and Norman Kirkby and Mike Merchant and Amy Chadwick and Matthew Lowe and Ranald Mackay and Jolyon Hendry and Karen Kirkby",
year = "2021",
month = feb,
day = "3",
doi = "10.1088/1361-6560/abe2ea",
language = "English",
volume = "66",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd",

}

RIS

TY - JOUR

T1 - Determining the parameter space for effective oxygen depletion for FLASH radiation therapy

AU - Rothwell, Bethany

AU - Kirkby, Norman

AU - Merchant, Mike

AU - Chadwick, Amy

AU - Lowe, Matthew

AU - Mackay, Ranald

AU - Hendry, Jolyon

AU - Kirkby, Karen

PY - 2021/2/3

Y1 - 2021/2/3

N2 - There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxygen depletion paradigm of induced radioresistance. An example eight-dimensional parameter space demonstrates the conditions under which radiation may induce sufficient depletion of oxygen for a diffusion-limited hypoxic cellular response. Initial results support experimental evidence that FLASH sparing is only achieved for dose rates on the order of tens of Gy/s or higher, for a sufficiently high dose, and only for tissue that is slightly hypoxic at the time of radiation. We show that the FLASH effect is the result of a number of biological, radiochemical and delivery parameters. Also, the threshold dose for a FLASH effect occurring would be more prominent when the parameterisation was optimised to produce the maximum effect. The model provides a framework for further FLASH-related investigation and experimental design. An understanding of the mechanistic interactions producing an optimised FLASH effect is essential for its translation into clinical practice.

AB - There has been a recent revival of interest in the FLASH effect, after experiments have shown normal tissue sparing capabilities of ultra-high-dose-rate radiation with no compromise on tumour growth restraint. A model has been developed to investigate the relative importance of a number of fundamental parameters considered to be involved in the oxygen depletion paradigm of induced radioresistance. An example eight-dimensional parameter space demonstrates the conditions under which radiation may induce sufficient depletion of oxygen for a diffusion-limited hypoxic cellular response. Initial results support experimental evidence that FLASH sparing is only achieved for dose rates on the order of tens of Gy/s or higher, for a sufficiently high dose, and only for tissue that is slightly hypoxic at the time of radiation. We show that the FLASH effect is the result of a number of biological, radiochemical and delivery parameters. Also, the threshold dose for a FLASH effect occurring would be more prominent when the parameterisation was optimised to produce the maximum effect. The model provides a framework for further FLASH-related investigation and experimental design. An understanding of the mechanistic interactions producing an optimised FLASH effect is essential for its translation into clinical practice.

U2 - 10.1088/1361-6560/abe2ea

DO - 10.1088/1361-6560/abe2ea

M3 - Article

VL - 66

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

M1 - 055020

ER -