Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution

Research output: Contribution to journalArticle

  • Authors:
  • Marina Alexeeva
  • Alexis Enright
  • Michael J. Dawson
  • Mahmoud Mahmoudian
  • Nicholas J. Turner

Abstract

Both the catalytic activity and enantioselectivity of the amine oxidase used in the deracemization, of D,L-α-methylbenzylamine (see scheme) have been enhanced by in vitro evolution methods to give α-methylbenzyamine in 77 % yield and 93 % ee.

Bibliographical metadata

Original languageEnglish
Pages (from-to)3177-3180
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number17
DOIs
Publication statusPublished - 2 Sep 2002