(De)constructing the blastocystCitation formats

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(De)constructing the blastocyst : Lessons in self-organization from the mouse. / Plusa, Berenika; Hadjantonakis, Anna Katerina.

In: Current Opinion in Systems Biology, Vol. 11, 10.2018, p. 98-106.

Research output: Contribution to journalReview article

Harvard

Plusa, B & Hadjantonakis, AK 2018, '(De)constructing the blastocyst: Lessons in self-organization from the mouse' Current Opinion in Systems Biology, vol. 11, pp. 98-106. https://doi.org/10.1016/j.coisb.2018.08.002

APA

Vancouver

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Plusa, Berenika ; Hadjantonakis, Anna Katerina. / (De)constructing the blastocyst : Lessons in self-organization from the mouse. In: Current Opinion in Systems Biology. 2018 ; Vol. 11. pp. 98-106.

Bibtex

@article{9153924379474220b166ddca72643d51,
title = "(De)constructing the blastocyst: Lessons in self-organization from the mouse",
abstract = "Mammalian pre-implantation development - from the zygote to the blastocyst - offers a simple, tractable model for investigating how cell fate specification is coordinated across a population, and how it is integrated with morphogenetic events, at single-cell resolution. Mouse zygotes cultured ex utero in the absence of extrinsic factors readily develop to the blastocyst stage, mimicking events taking place in utero. This remarkable feature of the earliest stages of mammalian development represents a paradigm of an evolutionarily-conserved program of self-organization. At the centre of this self-organizing ability lies an extraordinarily labile developmental program, which can sense and respond to perturbations. To date, the blastocyst is also the only embryonic stage and of any species, from which stem cells representing each of its constituent lineages can be captured and propagated in vitro. Gaining insights into the mechanistic underpinnings of blastocyst development underscores our understanding of the inherent flexibility and robustness in the intrinsic developmental program in vivo, and underscores methods to recapitulate it in vitro.",
keywords = "Blastocyst, Cell lineage specification, Epiblast, Inner cell mass, Mammalian embryo, Pre-implantation development, Primitive endoderm, Regulative development, Trophectoderm",
author = "Berenika Plusa and Hadjantonakis, {Anna Katerina}",
year = "2018",
month = "10",
doi = "10.1016/j.coisb.2018.08.002",
language = "English",
volume = "11",
pages = "98--106",
journal = "Current Opinion in Systems Biology",
issn = "2452-3100",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - (De)constructing the blastocyst

T2 - Lessons in self-organization from the mouse

AU - Plusa, Berenika

AU - Hadjantonakis, Anna Katerina

PY - 2018/10

Y1 - 2018/10

N2 - Mammalian pre-implantation development - from the zygote to the blastocyst - offers a simple, tractable model for investigating how cell fate specification is coordinated across a population, and how it is integrated with morphogenetic events, at single-cell resolution. Mouse zygotes cultured ex utero in the absence of extrinsic factors readily develop to the blastocyst stage, mimicking events taking place in utero. This remarkable feature of the earliest stages of mammalian development represents a paradigm of an evolutionarily-conserved program of self-organization. At the centre of this self-organizing ability lies an extraordinarily labile developmental program, which can sense and respond to perturbations. To date, the blastocyst is also the only embryonic stage and of any species, from which stem cells representing each of its constituent lineages can be captured and propagated in vitro. Gaining insights into the mechanistic underpinnings of blastocyst development underscores our understanding of the inherent flexibility and robustness in the intrinsic developmental program in vivo, and underscores methods to recapitulate it in vitro.

AB - Mammalian pre-implantation development - from the zygote to the blastocyst - offers a simple, tractable model for investigating how cell fate specification is coordinated across a population, and how it is integrated with morphogenetic events, at single-cell resolution. Mouse zygotes cultured ex utero in the absence of extrinsic factors readily develop to the blastocyst stage, mimicking events taking place in utero. This remarkable feature of the earliest stages of mammalian development represents a paradigm of an evolutionarily-conserved program of self-organization. At the centre of this self-organizing ability lies an extraordinarily labile developmental program, which can sense and respond to perturbations. To date, the blastocyst is also the only embryonic stage and of any species, from which stem cells representing each of its constituent lineages can be captured and propagated in vitro. Gaining insights into the mechanistic underpinnings of blastocyst development underscores our understanding of the inherent flexibility and robustness in the intrinsic developmental program in vivo, and underscores methods to recapitulate it in vitro.

KW - Blastocyst

KW - Cell lineage specification

KW - Epiblast

KW - Inner cell mass

KW - Mammalian embryo

KW - Pre-implantation development

KW - Primitive endoderm

KW - Regulative development

KW - Trophectoderm

UR - http://www.scopus.com/inward/record.url?scp=85054006022&partnerID=8YFLogxK

U2 - 10.1016/j.coisb.2018.08.002

DO - 10.1016/j.coisb.2018.08.002

M3 - Review article

VL - 11

SP - 98

EP - 106

JO - Current Opinion in Systems Biology

JF - Current Opinion in Systems Biology

SN - 2452-3100

ER -