Deciphering the roles of multiple additives in organocatalyzed Michael additions

Research output: Research - peer-reviewArticle

  • External authors:
  • Z. Inci Gunler
  • Xavier Companyo
  • Ignacio Alfonso
  • Ciril Jimeno
  • Miquel A. Pericas


The synergistic effects of multiple additives (water and acetic acid) on the asymmetric Michael addition of acetone to nitrostyrene catalyzed by primary amine-thioureas (PAT) were precisely determined. Acetic acid facilitates hydrolysis of the imine intermediates, thus leading to catalytic behavior, and minimizes the formation of the double addition side product. In contrast, water slows down the reaction but minimizes catalyst deactivation, eventually leading to higher final yields.

Bibliographical metadata

Original languageEnglish
Pages (from-to)6821-6824
Number of pages4
JournalChemical Communications
Issue number41
Early online date25 Apr 2016
StatePublished - 21 May 2016