Decarboxylative C-H cross-coupling of azoles

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(Figure Presented) Côte d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2768-2771
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number15
Publication statusPublished - 1 Apr 2010