Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort studyCitation formats

  • External authors:
  • Nicolaos C. Nicolaou
  • Lesley A. Lowe
  • Ashley Woodcock
  • Adnan Custovic

Standard

Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study. / Nicolaou, Nicolaos C.; Simpson, Angela; Lowe, Lesley A.; Murray, Clare S.; Woodcock, Ashley; Custovic, Adnan.

In: Journal of Allergy and Clinical Immunology, Vol. 122, No. 3, 09.2008, p. 500-506.

Research output: Contribution to journalArticle

Harvard

Nicolaou, NC, Simpson, A, Lowe, LA, Murray, CS, Woodcock, A & Custovic, A 2008, 'Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study', Journal of Allergy and Clinical Immunology, vol. 122, no. 3, pp. 500-506. https://doi.org/10.1016/j.jaci.2008.06.033

APA

Nicolaou, N. C., Simpson, A., Lowe, L. A., Murray, C. S., Woodcock, A., & Custovic, A. (2008). Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study. Journal of Allergy and Clinical Immunology, 122(3), 500-506. https://doi.org/10.1016/j.jaci.2008.06.033

Vancouver

Nicolaou NC, Simpson A, Lowe LA, Murray CS, Woodcock A, Custovic A. Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study. Journal of Allergy and Clinical Immunology. 2008 Sep;122(3):500-506. https://doi.org/10.1016/j.jaci.2008.06.033

Author

Nicolaou, Nicolaos C. ; Simpson, Angela ; Lowe, Lesley A. ; Murray, Clare S. ; Woodcock, Ashley ; Custovic, Adnan. / Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study. In: Journal of Allergy and Clinical Immunology. 2008 ; Vol. 122, No. 3. pp. 500-506.

Bibtex

@article{d724cdab8aae4f948b66ea45cf29c547,
title = "Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study",
abstract = "Background: There are conflicting data on the effect of day-care attendance and position in sibship on the development of wheezing. Objective: To investigate the relationship between day-care attendance and position in sibship with early childhood wheeze. Methods: Prospective population-based birth cohort. At age 5 years, we collected information on parentally reported symptoms (n = 922); lung function was ascertained using plethysmography (n = 745) and allergic sensitization by skin testing (n = 815). Participants were assigned into categories according to the age of entry to day-care (0-6, 6-12, >12 mo) and number of older siblings (0, 1, 2, >2). Results: Current wheeze was reported by 203 participants (22{\%}); 224 (28{\%}) were sensitized. In the multivariate model, sensitization (odds ratio, 2.47; 95{\%} CI, 1.66-3.67), male sex (1.49, 1.01-2.20), maternal asthma (1.72, 1.10-2.68), and maternal smoking during pregnancy (2.15, 1.26-3.66) significantly increased the risk of wheezing. Entering day-care between 6 and 12 or after 12 months of age was significantly and inversely associated with current wheeze (0.25, 0.11-0.60; and 0.65, 0.44-0.98, respectively). Entry into nursery between 6 and 12 months reduced the risk of persistent wheezing (P = .04). We found no association between day-care attendance and lung function. Entering nursery in the first 6 months of life was associated with increased risk of atopy (2.47, 1.23-4.95). Having older siblings was associated only with rhinoconjunctivitis (0.72, 0.54-0.97). Conclusion: Day-care attendance was associated with a reduced risk of current wheezing in 5-year-old children. The protective effect appeared strongest for children who entered day-care between the ages of 6 and 12 months. {\circledC} 2008 American Academy of Allergy, Asthma & Immunology.",
keywords = "birth cohort, Day-care, siblings, wheezing",
author = "Nicolaou, {Nicolaos C.} and Angela Simpson and Lowe, {Lesley A.} and Murray, {Clare S.} and Ashley Woodcock and Adnan Custovic",
year = "2008",
month = "9",
doi = "10.1016/j.jaci.2008.06.033",
language = "English",
volume = "122",
pages = "500--506",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Day-care attendance, position in sibship, and early childhood wheezing: A population-based birth cohort study

AU - Nicolaou, Nicolaos C.

AU - Simpson, Angela

AU - Lowe, Lesley A.

AU - Murray, Clare S.

AU - Woodcock, Ashley

AU - Custovic, Adnan

PY - 2008/9

Y1 - 2008/9

N2 - Background: There are conflicting data on the effect of day-care attendance and position in sibship on the development of wheezing. Objective: To investigate the relationship between day-care attendance and position in sibship with early childhood wheeze. Methods: Prospective population-based birth cohort. At age 5 years, we collected information on parentally reported symptoms (n = 922); lung function was ascertained using plethysmography (n = 745) and allergic sensitization by skin testing (n = 815). Participants were assigned into categories according to the age of entry to day-care (0-6, 6-12, >12 mo) and number of older siblings (0, 1, 2, >2). Results: Current wheeze was reported by 203 participants (22%); 224 (28%) were sensitized. In the multivariate model, sensitization (odds ratio, 2.47; 95% CI, 1.66-3.67), male sex (1.49, 1.01-2.20), maternal asthma (1.72, 1.10-2.68), and maternal smoking during pregnancy (2.15, 1.26-3.66) significantly increased the risk of wheezing. Entering day-care between 6 and 12 or after 12 months of age was significantly and inversely associated with current wheeze (0.25, 0.11-0.60; and 0.65, 0.44-0.98, respectively). Entry into nursery between 6 and 12 months reduced the risk of persistent wheezing (P = .04). We found no association between day-care attendance and lung function. Entering nursery in the first 6 months of life was associated with increased risk of atopy (2.47, 1.23-4.95). Having older siblings was associated only with rhinoconjunctivitis (0.72, 0.54-0.97). Conclusion: Day-care attendance was associated with a reduced risk of current wheezing in 5-year-old children. The protective effect appeared strongest for children who entered day-care between the ages of 6 and 12 months. © 2008 American Academy of Allergy, Asthma & Immunology.

AB - Background: There are conflicting data on the effect of day-care attendance and position in sibship on the development of wheezing. Objective: To investigate the relationship between day-care attendance and position in sibship with early childhood wheeze. Methods: Prospective population-based birth cohort. At age 5 years, we collected information on parentally reported symptoms (n = 922); lung function was ascertained using plethysmography (n = 745) and allergic sensitization by skin testing (n = 815). Participants were assigned into categories according to the age of entry to day-care (0-6, 6-12, >12 mo) and number of older siblings (0, 1, 2, >2). Results: Current wheeze was reported by 203 participants (22%); 224 (28%) were sensitized. In the multivariate model, sensitization (odds ratio, 2.47; 95% CI, 1.66-3.67), male sex (1.49, 1.01-2.20), maternal asthma (1.72, 1.10-2.68), and maternal smoking during pregnancy (2.15, 1.26-3.66) significantly increased the risk of wheezing. Entering day-care between 6 and 12 or after 12 months of age was significantly and inversely associated with current wheeze (0.25, 0.11-0.60; and 0.65, 0.44-0.98, respectively). Entry into nursery between 6 and 12 months reduced the risk of persistent wheezing (P = .04). We found no association between day-care attendance and lung function. Entering nursery in the first 6 months of life was associated with increased risk of atopy (2.47, 1.23-4.95). Having older siblings was associated only with rhinoconjunctivitis (0.72, 0.54-0.97). Conclusion: Day-care attendance was associated with a reduced risk of current wheezing in 5-year-old children. The protective effect appeared strongest for children who entered day-care between the ages of 6 and 12 months. © 2008 American Academy of Allergy, Asthma & Immunology.

KW - birth cohort

KW - Day-care

KW - siblings

KW - wheezing

U2 - 10.1016/j.jaci.2008.06.033

DO - 10.1016/j.jaci.2008.06.033

M3 - Article

VL - 122

SP - 500

EP - 506

JO - Journal of Allergy and Clinical Immunology

T2 - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3

ER -