Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solventsCitation formats

  • External authors:
  • M. J. Guppy
  • M. Wood
  • C. Knight
  • C. M. Black
  • A. J. Silman

Standard

Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. / Povey, A.; Guppy, M. J.; Wood, M.; Knight, C.; Black, C. M.; Silman, A. J.

In: Arthritis Care & Research, Vol. 44, No. 3, 2001, p. 662-665.

Research output: Contribution to journalArticle

Harvard

Povey, A, Guppy, MJ, Wood, M, Knight, C, Black, CM & Silman, AJ 2001, 'Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents', Arthritis Care & Research, vol. 44, no. 3, pp. 662-665. https://doi.org/10.1002/1529-0131(200103)44:3<662::AID-ANR115>3.0.CO;2-P

APA

Povey, A., Guppy, M. J., Wood, M., Knight, C., Black, C. M., & Silman, A. J. (2001). Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. Arthritis Care & Research, 44(3), 662-665. https://doi.org/10.1002/1529-0131(200103)44:3<662::AID-ANR115>3.0.CO;2-P

Vancouver

Author

Povey, A. ; Guppy, M. J. ; Wood, M. ; Knight, C. ; Black, C. M. ; Silman, A. J. / Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. In: Arthritis Care & Research. 2001 ; Vol. 44, No. 3. pp. 662-665.

Bibtex

@article{9caedbc2b6c94abbb0fd1769363d5720,
title = "Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents",
abstract = "Objective. To determine whether there are specific cytochrome P450 (CYP2) alleles that increase susceptibility to scleroderma in individuals who have been exposed to organic solvents. Methods. CYP alleles at 2 loci, 2E1 and 2C19, were compared in 7 patients who had developed scleroderma after exposure to solvents versus 71 patients with scleroderma without solvent exposure ({"}sporadic{"} disease) and 106 population controls. Results. The 2E1*3 allele was found in 2 of the 7 patients who had been exposed to organic solvents, with a greater frequency than occurred in either the disease controls or the population controls (odds ratio [95% confidence interval] 9.1 [1.5-59.1] and 10.2 [1.8-62.2], respectively). All 7 patients with solvent exposure carried the 2C19EM genotype, compared with 89% of patients with sporadic scleroderma. Conclusion. Our results suggest that alleles at CYP loci may be involved in increasing susceptibility to scleroderma among subjects who have been exposed to organic solvents.",
keywords = "Case-Control Studies, Comparative Study, Cytochrome P-450 Enzyme System/*genetics, Disease Susceptibility/*chemically induced, Environmental Exposure/adverse effects, Human, Polymorphism (Genetics), Scleroderma, Systemic/*chemically induced, Solvents/*adverse effects, Support, Non-U.S. Gov't",
author = "A. Povey and Guppy, {M. J.} and M. Wood and C. Knight and Black, {C. M.} and Silman, {A. J.}",
year = "2001",
doi = "10.1002/1529-0131(200103)44:3<662::AID-ANR115>3.0.CO;2-P",
language = "English",
volume = "44",
pages = "662--665",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "John Wiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents

AU - Povey, A.

AU - Guppy, M. J.

AU - Wood, M.

AU - Knight, C.

AU - Black, C. M.

AU - Silman, A. J.

PY - 2001

Y1 - 2001

N2 - Objective. To determine whether there are specific cytochrome P450 (CYP2) alleles that increase susceptibility to scleroderma in individuals who have been exposed to organic solvents. Methods. CYP alleles at 2 loci, 2E1 and 2C19, were compared in 7 patients who had developed scleroderma after exposure to solvents versus 71 patients with scleroderma without solvent exposure ("sporadic" disease) and 106 population controls. Results. The 2E1*3 allele was found in 2 of the 7 patients who had been exposed to organic solvents, with a greater frequency than occurred in either the disease controls or the population controls (odds ratio [95% confidence interval] 9.1 [1.5-59.1] and 10.2 [1.8-62.2], respectively). All 7 patients with solvent exposure carried the 2C19EM genotype, compared with 89% of patients with sporadic scleroderma. Conclusion. Our results suggest that alleles at CYP loci may be involved in increasing susceptibility to scleroderma among subjects who have been exposed to organic solvents.

AB - Objective. To determine whether there are specific cytochrome P450 (CYP2) alleles that increase susceptibility to scleroderma in individuals who have been exposed to organic solvents. Methods. CYP alleles at 2 loci, 2E1 and 2C19, were compared in 7 patients who had developed scleroderma after exposure to solvents versus 71 patients with scleroderma without solvent exposure ("sporadic" disease) and 106 population controls. Results. The 2E1*3 allele was found in 2 of the 7 patients who had been exposed to organic solvents, with a greater frequency than occurred in either the disease controls or the population controls (odds ratio [95% confidence interval] 9.1 [1.5-59.1] and 10.2 [1.8-62.2], respectively). All 7 patients with solvent exposure carried the 2C19EM genotype, compared with 89% of patients with sporadic scleroderma. Conclusion. Our results suggest that alleles at CYP loci may be involved in increasing susceptibility to scleroderma among subjects who have been exposed to organic solvents.

KW - Case-Control Studies

KW - Comparative Study

KW - Cytochrome P-450 Enzyme System/genetics

KW - Disease Susceptibility/chemically induced

KW - Environmental Exposure/adverse effects

KW - Human

KW - Polymorphism (Genetics)

KW - Scleroderma, Systemic/chemically induced

KW - Solvents/adverse effects

KW - Support, Non-U.S. Gov't

U2 - 10.1002/1529-0131(200103)44:3<662::AID-ANR115>3.0.CO;2-P

DO - 10.1002/1529-0131(200103)44:3<662::AID-ANR115>3.0.CO;2-P

M3 - Article

VL - 44

SP - 662

EP - 665

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 3

ER -