Cueing emotional memories during slow wave sleep modulates next-day activity in the orbitofrontal cortex and the amygdalaCitation formats

  • External authors:
  • Sofia Isabel Ribeiro Pereira
  • Maria-efstratia Tsimpanouli
  • Isabel Hutchison
  • Jules Schneider
  • Penelope A. Lewis

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Cueing emotional memories during slow wave sleep modulates next-day activity in the orbitofrontal cortex and the amygdala. / Pereira, Sofia Isabel Ribeiro; Tsimpanouli, Maria-efstratia; Hutchison, Isabel; Schneider, Jules; Anderson, Ian M.; Mcfarquhar, Martyn; Elliott, Rebecca; Lewis, Penelope A.

In: NeuroImage, Vol. 253, 119120, 01.06.2022.

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Pereira, Sofia Isabel Ribeiro ; Tsimpanouli, Maria-efstratia ; Hutchison, Isabel ; Schneider, Jules ; Anderson, Ian M. ; Mcfarquhar, Martyn ; Elliott, Rebecca ; Lewis, Penelope A. / Cueing emotional memories during slow wave sleep modulates next-day activity in the orbitofrontal cortex and the amygdala. In: NeuroImage. 2022 ; Vol. 253.

Bibtex

@article{5daadc2740a04e8fbcbc253c7030de5d,
title = "Cueing emotional memories during slow wave sleep modulates next-day activity in the orbitofrontal cortex and the amygdala",
abstract = "Emotional memories are preferentially consolidated during sleep, through the process of memory reactivation. Targeted memory reactivation (TMR) has been shown to boost memory consolidation during sleep, but its neural correlates remain unclear, particularly for emotional memories. Here, we aimed to examine how TMR of emotional material during slow wave sleep (SWS) impacts upon neural processing during a subsequent arousal rating task. Participants were trained on a spatial memory task including negative and neutral pictures paired with semantically matching sounds. The picture-sound pairs were rated for emotional arousal before and after the spatial memory task. Then, half of the sounds from each emotional category (negative and neutral) were cued during SWS. The next day, participants were retested on both the arousal rating and the spatial memory task inside an MRI scanner, followed by another retest session a week later. Memory consolidation and arousal processing did not differ between cued and non-cued items of either emotional category. We found increased responses to emotional stimuli in the amygdala and orbitofrontal cortex (OFC), and a cueing versus emotion interaction in the OFC, whereby cueing neutral stimuli led to an increase in OFC activity, while cueing negative stimuli led to decreased OFC activation. Interestingly, the effect of cueing on amygdala activation was modulated by time spent in REM sleep. We conclude that SWS TMR impacts OFC activity, while REM sleep plays a role in mediating the effect of such cueing on amygdala.",
author = "Pereira, {Sofia Isabel Ribeiro} and Maria-efstratia Tsimpanouli and Isabel Hutchison and Jules Schneider and Anderson, {Ian M.} and Martyn Mcfarquhar and Rebecca Elliott and Lewis, {Penelope A.}",
year = "2022",
month = jun,
day = "1",
doi = "10.1016/j.neuroimage.2022.119120",
language = "English",
volume = "253",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Cueing emotional memories during slow wave sleep modulates next-day activity in the orbitofrontal cortex and the amygdala

AU - Pereira, Sofia Isabel Ribeiro

AU - Tsimpanouli, Maria-efstratia

AU - Hutchison, Isabel

AU - Schneider, Jules

AU - Anderson, Ian M.

AU - Mcfarquhar, Martyn

AU - Elliott, Rebecca

AU - Lewis, Penelope A.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Emotional memories are preferentially consolidated during sleep, through the process of memory reactivation. Targeted memory reactivation (TMR) has been shown to boost memory consolidation during sleep, but its neural correlates remain unclear, particularly for emotional memories. Here, we aimed to examine how TMR of emotional material during slow wave sleep (SWS) impacts upon neural processing during a subsequent arousal rating task. Participants were trained on a spatial memory task including negative and neutral pictures paired with semantically matching sounds. The picture-sound pairs were rated for emotional arousal before and after the spatial memory task. Then, half of the sounds from each emotional category (negative and neutral) were cued during SWS. The next day, participants were retested on both the arousal rating and the spatial memory task inside an MRI scanner, followed by another retest session a week later. Memory consolidation and arousal processing did not differ between cued and non-cued items of either emotional category. We found increased responses to emotional stimuli in the amygdala and orbitofrontal cortex (OFC), and a cueing versus emotion interaction in the OFC, whereby cueing neutral stimuli led to an increase in OFC activity, while cueing negative stimuli led to decreased OFC activation. Interestingly, the effect of cueing on amygdala activation was modulated by time spent in REM sleep. We conclude that SWS TMR impacts OFC activity, while REM sleep plays a role in mediating the effect of such cueing on amygdala.

AB - Emotional memories are preferentially consolidated during sleep, through the process of memory reactivation. Targeted memory reactivation (TMR) has been shown to boost memory consolidation during sleep, but its neural correlates remain unclear, particularly for emotional memories. Here, we aimed to examine how TMR of emotional material during slow wave sleep (SWS) impacts upon neural processing during a subsequent arousal rating task. Participants were trained on a spatial memory task including negative and neutral pictures paired with semantically matching sounds. The picture-sound pairs were rated for emotional arousal before and after the spatial memory task. Then, half of the sounds from each emotional category (negative and neutral) were cued during SWS. The next day, participants were retested on both the arousal rating and the spatial memory task inside an MRI scanner, followed by another retest session a week later. Memory consolidation and arousal processing did not differ between cued and non-cued items of either emotional category. We found increased responses to emotional stimuli in the amygdala and orbitofrontal cortex (OFC), and a cueing versus emotion interaction in the OFC, whereby cueing neutral stimuli led to an increase in OFC activity, while cueing negative stimuli led to decreased OFC activation. Interestingly, the effect of cueing on amygdala activation was modulated by time spent in REM sleep. We conclude that SWS TMR impacts OFC activity, while REM sleep plays a role in mediating the effect of such cueing on amygdala.

U2 - 10.1016/j.neuroimage.2022.119120

DO - 10.1016/j.neuroimage.2022.119120

M3 - Article

VL - 253

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 119120

ER -