Crystallization in polymorphic systems: The solution-mediated transformation of β to α glycine

Research output: Contribution to journalArticle

  • Authors:
  • Elena S. Ferrari
  • Roger J. Davey
  • Wendy I. Cross
  • Amy L. Gillon
  • Christopher S. Towler

Abstract

The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the (α form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable β polymorph.

Bibliographical metadata

Original languageEnglish
Pages (from-to)53-60
Number of pages7
JournalCrystal Growth and Design
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2003

Related information